Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
11228490
TITLE
An Australian twin study of the genetic basis of preeclampsia and eclampsia.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
We investigated maternal versus fetal genetic causes of preeclampsia and eclampsia by assessing concordance between monozygotic and dizygotic female co-twins, between female partners of male monozygotic and dizygotic twin pairs, and between female twins and partners of their male co-twins in dizygotic opposite-sex pairs.
STUDY DESIGN NlmCategory: METHODS
Two large birth cohorts of volunteer Australian female twin pairs (N = 1504 pairs and N = 858 pairs) were screened and interviewed, and available medical and hospital records were obtained and reviewed where indicated, with diagnoses assigned according to predetermined criteria.
RESULTS NlmCategory: RESULTS
With strict diagnostic criteria used for preeclampsia and eclampsia, no concordant female twin pairs were found. Collapsing diagnoses of definite, probable, or possible preeclampsia or eclampsia resulted in very low genetic recurrence risk estimates.
CONCLUSION NlmCategory: CONCLUSIONS
Results from these two cohorts of female twin pairs do not support clear, solely maternal genetic influences on preeclampsia and eclampsia. Numbers of parous female partners of male twins were too low for conclusions to be drawn regarding paternal transmission.
DATE PUBLISHED
2001 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2001/03/03 10:00
medline 2001/04/03 10:01
entrez 2001/03/03 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Treloar SA Treloar S A SA Queensland Institute of Medical Research and the Joint Genetics Program, The University of Queensland, Brisbane, Australia.
Cooper DW Cooper D W DW
Brennecke SP Brennecke S P SP
Grehan MM Grehan M M MM
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 184
ISSUE: 3
TITLE: American journal of obstetrics and gynecology
ISOABBREVIATION: Am. J. Obstet. Gynecol.
YEAR: 2001
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0002-9378
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Obstet Gynecol
COUNTRY: UNITED STATES
ISSNLINKING: 0002-9378
NLMUNIQUEID: 0370476
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia epidemiology
Cohort Studies epidemiology
Diseases in Twins genetics
Eclampsia genetics
Fathers genetics
Female genetics
Humans genetics
Interviews as Topic genetics
Male genetics
Pre-Eclampsia genetics
Pregnancy genetics
Questionnaires genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's