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| PMID |
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| TITLE |
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| Dizygotic twinning is not linked to variation at the alpha-inhibin locus on human chromosome 2. |
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| ABSTRACT |
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| Natural multiple pregnancy in women leading to dizygotic (DZ) twins is familial and varies across racial groups, suggesting a genetic predisposition. Mothers of DZ twins have a higher incidence of spontaneous multiple ovulation and elevated FSH concentrations. FSH release is controlled by feedback of inhibin peptides from the ovary, and immunization against inhibin alpha-subunit results in an increased ovulation rate in animals. The inhibin alpha-subunit is therefore a candidate gene for mutations that may increase the frequency of DZ twinning. Restriction digests of a PCR product from exon 1 with the enzyme SpeI detects a C/T polymorphism at bp 128 with two alleles of 447 and 323/124 bp. The polymorphism was typed in 1,125 individuals from 326 pedigrees with 717 mothers of spontaneous DZ twins. The alpha-inhibin locus mapped within 3 centimorgans of D2S164, and linkage with DZ twinning was excluded [decimal log odds ratio (LOD) score, -2.81 at theta = 0]. There was complete exclusion of linkage (LOD, less than -2) of a gene conferring relative risk 1.8 (lambdas, >1.8) across the chromosome, except at the p-terminus region and a small peak (maximum LOD score, 0.6) in the region of D2S151-D2S326. Analysis using either recessive or dominant models excluded linkage with DZ twinning in this population (LOD score, less than -2.5) across chromosome 2. We conclude that dizygotic twinning is not linked to variation in the alpha-inhibin locus. The results also suggest that mutations in other candidates on chromosome 2, including the receptor for FSH and the betaB-inhibin subunit (INHBB) cannot be major contributors to risk for DZ twinning. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2000/09/22 11:00 |
| medline |
2000/10/21 11:01 |
| entrez |
2000/09/22 11:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Montgomery GW |
|
Montgomery |
G W |
GW |
|
Genetic Epidemiology Laboratory, Queensland Institute of Medical Research and Joint Genetics Program, University of Queensland, Brisbane, Australia. grantM@qimr.edu.au |
| Duffy DL |
|
Duffy |
D L |
DL |
|
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| Hall J |
|
Hall |
J |
J |
|
|
| Haddon BR |
|
Haddon |
B R |
BR |
|
|
| Kudo M |
|
Kudo |
M |
M |
|
|
| McGee EA |
|
McGee |
E A |
EA |
|
|
| Palmer JS |
|
Palmer |
J S |
JS |
|
|
| Hsueh AJ |
|
Hsueh |
A J |
AJ |
|
|
| Boomsma DI |
|
Boomsma |
D I |
DI |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 85 |
| ISSUE: 9 |
| TITLE: The Journal of clinical endocrinology and metabolism |
| ISOABBREVIATION: J. Clin. Endocrinol. Metab. |
| YEAR: 2000 |
| MONTH: Sep |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0021-972X |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: J Clin Endocrinol Metab |
| COUNTRY: United States |
| ISSNLINKING: 0021-972X |
| NLMUNIQUEID: 0375362 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Clinical Trial |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Chromosome Mapping |
|
| Chromosomes, Human, Pair 2 |
genetics |
| DNA |
genetics |
| Exons |
genetics |
| Female |
genetics |
| Genetic Linkage |
genetics |
| Genome |
genetics |
| Humans |
genetics |
| Inhibins |
genetics |
| Pedigree |
genetics |
| Polymorphism, Genetic |
genetics |
| Pregnancy |
genetics |
| Receptors, FSH |
genetics |
| Reverse Transcriptase Polymerase Chain Reaction |
genetics |
| Twins, Dizygotic |
genetics |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
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| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Receptors, FSH |
| 57285-09-3 |
Inhibins |
| 9007-49-2 |
DNA |
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| OTHER ID's |
|
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