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| PMID |
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| TITLE |
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| Genetic influences on premature parturition in an Australian twin sample. |
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| ABSTRACT |
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| We investigated possible genetic influences on women's liability to preterm birth, using data from a large sample of Australian female twin pairs. In a 1988-90 questionnaire survey, both members of 905 parous twin pairs (579 monozygotic and 326 dizygotic) reported on whether deliveries had been more than two weeks preterm. Tetrachoric twin pair correlations for first birth were rMZ = 0.20+/-0.11 and rDZ = -0.03+/-0.14, and for any birth were rMZ = 0.30+/-0.08 and rDZ = 0.03+/-0.11. Best-fitting models to data contained only additive genetic influences and individual environmental effects. Heritability was 17% for preterm delivery in first pregnancy, and 27% for preterm delivery in any pregnancy. In the former case, however, we could not reject a model without genetic influences. Although our data did not allow for differentiation of the varying aetiologies of premature parturition, results from this exploratory analysis suggest that further investigation of genetic influences on specific reasons for preterm birth is warranted. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2000/08/06 11:00 |
| medline |
2001/02/28 10:01 |
| entrez |
2000/08/06 11:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Treloar SA |
|
Treloar |
S A |
SA |
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Queensland Institute of Medical Research and Joint Genetics Program, The University of Queensland, Brisbane, Australia. sueT@qimr.edu.au |
| Macones GA |
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Macones |
G A |
GA |
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| Mitchell LE |
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Mitchell |
L E |
LE |
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| Martin NG |
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Martin |
N G |
NG |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 3 |
| ISSUE: 2 |
| TITLE: Twin research : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res |
| YEAR: 2000 |
| MONTH: Jun |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1369-0523 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res |
| COUNTRY: Australia |
| ISSNLINKING: 1369-0523 |
| NLMUNIQUEID: 9815819 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
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| Aged |
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| Aged, 80 and over |
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| Australia |
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| Chi-Square Distribution |
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| Diseases in Twins |
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| Environment |
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| Female |
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| Humans |
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| Least-Squares Analysis |
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| Middle Aged |
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| Models, Genetic |
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| Obstetric Labor, Premature |
genetics |
| Parity |
genetics |
| Pregnancy |
genetics |
| Retrospective Studies |
genetics |
| Statistics, Nonparametric |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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