Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
10857247
TITLE
The genetics of smoking persistence in men and women: a multicultural study.
ABSTRACT
Using a correlated liability dimensions model, we examined the extent to which the same genetic and environmental factors influence both initiation of regular cigarette smoking and maintenance of the smoking habit in men and women. We analyzed questionnaire survey data obtained from large samples of male and female like-sexed twins from three countries, Australia (N = 1535 pairs), Sweden (N = 5916 pairs), and Finland (N = 4438 pairs), subdivided into three age bands (18-25, 26-35, and 36-46 years of age). We found that familial influences on risk for persistence in smoking cannot be entirely explained by the same factors responsible for risk of smoking initiation. Total genetic variance for smoking persistence varied little by age band and sex (range, 39-49% in women and 42-45% in men); however, even among twins in the youngest group (18-25 years of age), who on average have the fewest years of cigarette use, less than 40% of the total genetic variance in smoking persistence was accounted for by the same genetic factors that increased risk of smoking initiation, and this percentage decreased to less than 10% in the 36-46 year olds.
DATE PUBLISHED
1999 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2000/06/17 09:00
medline 2000/07/25 11:00
entrez 2000/06/17 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Madden PA Madden P A PA Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. pam@matlock.wustl.edu
Heath AC Heath A C AC
Pedersen NL Pedersen N L NL
Kaprio J Kaprio J J
Koskenvuo MJ Koskenvuo M J MJ
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 29
ISSUE: 6
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 1999
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-8244
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
DA00272 NIDA NIH HHS United States
DA12540 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Cross-Cultural Comparison
Diseases in Twins genetics
Female genetics
Genetic Predisposition to Disease genetics
Humans genetics
Male genetics
Middle Aged genetics
Risk Factors genetics
Smoking psychology
Social Environment psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's