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PMID |
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TITLE |
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Genetic and environmental causes of variation in basal levels of blood cells. |
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ABSTRACT |
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The genetic and environmental determinants of variation in blood cell size and number were investigated in 392 pairs of 12-year-old twins. The following blood cell indices were measured: haemoglobin, red blood cell count, haematocrit, mean corpuscular volume, platelet number, total white cell count, level of neutrophils, monocytes, eosinophils, total lymphocytes, CD3+ lymphocytes, CD4+ lymphocytes, CD8+ lymphocytes, CD19+ lymphocytes, CD56+ lymphocytes and CD4+/CD8+ ratio. Genetic factors contributed significantly to all blood cell measures accounting for between 61 and 96% of variance. Heritability estimates did not differ significantly between males and females, although the sample size of the present study was not large enough to exclude the possibility of sex-limited gene expression. Common environmental factors were important in determining red blood cell count and haematocrit, but were not important in determining basal levels of any white blood cell type. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
pubmed |
2000/03/21 09:00 |
medline |
2000/04/15 09:00 |
entrez |
2000/03/21 09:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Evans DM |
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Evans |
D M |
DM |
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Queensland Institute of Medical Research, University of Queensland, Brisbane, Australia. |
Frazer IH |
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Frazer |
I H |
IH |
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Martin NG |
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Martin |
N G |
NG |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 2 |
ISSUE: 4 |
TITLE: Twin research : the official journal of the International Society for Twin Studies |
ISOABBREVIATION: Twin Res |
YEAR: 1999 |
MONTH: Dec |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: 1369-0523 |
ISSNTYPE: Print |
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MEDLINE JOURNAL |
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MEDLINETA: Twin Res |
COUNTRY: Australia |
ISSNLINKING: 1369-0523 |
NLMUNIQUEID: 9815819 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, Non-U.S. Gov't |
Twin Study |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Antigens, CD |
genetics |
Blood Cell Count |
genetics |
Child |
genetics |
Erythrocyte Indices |
genetics |
Female |
genetics |
Genetics, Medical |
genetics |
Humans |
genetics |
Lymphocyte Subsets |
genetics |
Male |
genetics |
Twins, Dizygotic |
genetics |
Twins, Monozygotic |
genetics |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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REGISTRYNUMBER |
NAMEOFSUBSTANCE |
0 |
Antigens, CD |
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OTHER ID's |
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