Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
10722174
TITLE
Early sexual abuse and lifetime psychopathology: a co-twin-control study.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
This study was designed to determine lifetime prevalence of psychiatric disorders among twins who reported childhood sexual abuse (CSA), and to compare these rates with those among non-abused co-twins. The contribution of familial and individual-specific factors to reported sexual abuse was also examined.
METHOD NlmCategory: METHODS
Information about lifetime psychopathology and substance use was obtained by structured telephone interviews with 5995 Australian twins. Twins who reported a history of childhood sexual abuse (CSA) were contrasted on lifetime psychopathology with subjects without such a history; in addition, comparisons were made between same-sex twin pairs discordant for CSA.
RESULTS NlmCategory: RESULTS
A history of CSA was reported by 5.9% of the women and 2.5% of the men. In the sample as a whole, those reporting CSA were more likely to receive lifetime diagnoses of major depression, conduct disorder, panic disorder and alcoholism, and were more likely to report suicidal ideation and a history of suicide attempt. Abused women, but not men, were also more likely to report social phobia. When comparisons were restricted to non-abused co-twins, no differences in psychopathology were seen. However, rates of major depression, conduct disorder and suicidal ideation were higher if both co-twins were abused than if the respondent alone reported CSA. Model-fitting indicated that shared environmental factors influenced risk for reported CSA in women, but not in men.
CONCLUSION NlmCategory: CONCLUSIONS
The association between CSA and psychopathology arises at least in part through the influence of shared familial factors on both risk of victimization and risk of psychopathology.
DATE PUBLISHED
2000 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2000/03/18 09:00
medline 2000/04/15 09:00
entrez 2000/03/18 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Dinwiddie S Dinwiddie S S Finch University of Health Sciences Department of Psychiatry and Behavioral Sciences, Chicago Medical School, IL 60074-3095, USA.
Heath AC Heath A C AC
Dunne MP Dunne M P MP
Bucholz KK Bucholz K K KK
Madden PA Madden P A PA
Slutske WS Slutske W S WS
Bierut LJ Bierut L J LJ
Statham DB Statham D B DB
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 30
ISSUE: 1
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2000
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0033-2917
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Animals
Case-Control Studies
Cats
Child
Child Abuse, Sexual psychology
Crime Victims psychology
Female psychology
Humans psychology
Male psychology
Mental Disorders etiology
Sex Factors etiology
Suicide, Attempted psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's