Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
10611188
TITLE
Birth weight and age at menopause in Australian female twin pairs: exploration of the fetal origin hypothesis.
ABSTRACT
In a twin sample where duration of gestation can be controlled, a specific example of the fetal origins hypothesis concerning association between low birth weight and early age at menopause is explored. The hypothesis is based on the physiologically plausible path from intrauterine growth retardation and reduced numbers of primary follicles to an earlier menopause. The sample comprised 323 Australian female twin pairs where both co-twins had reached menopause naturally and reported on their weight at birth. Regression analysis showed no linear association between the two variables (P = 0.371, r(2) = 0.0009). Intra-pair differences in age at menopause were investigated in the context of relative birth weight of co-twins. In 265 pairs an intra-pair birth weight difference was reported. In monozygotic (MZ) pairs (n = 168) this allowed for control of genetic effects as well as gestation duration. No significant differences dependent on birth weight relative to co-twin were found for age at natural menopause in either MZ or dizygotic (DZ) twin pairs, even in pairs whose birth weights differed markedly. There was some indication that twins with premature ovarian failure were heavier at birth than twins with normal or later menopausal age. We conclude that the hypothesis that lower birth weight is associated with earlier menopause is not supported by our data.
DATE PUBLISHED
2000 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1999/12/28
medline 1999/12/28 00:01
entrez 1999/12/28 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Treloar SA Treloar S A SA Epidemiology and Population Health Unit, Queensland Institute of Medical Research and Joint Genetics Program, The University of Queensland, Brisbane, Australia.
Sadrzadeh S Sadrzadeh S S
Do KA Do K A KA
Martin NG Martin N G NG
Lambalk CB Lambalk C B CB
INVESTIGATORS
JOURNAL
VOLUME: 15
ISSUE: 1
TITLE: Human reproduction (Oxford, England)
ISOABBREVIATION: Hum. Reprod.
YEAR: 2000
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0268-1161
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Hum Reprod
COUNTRY: England
ISSNLINKING: 0268-1161
NLMUNIQUEID: 8701199
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Australia
Birth Weight
Female
Humans
Menopause physiology
Middle Aged physiology
Twins physiology
Twins, Dizygotic physiology
Twins, Monozygotic physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's