Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
1053249
TITLE
The inheritance of scholastic abilities in a sample of twins. II. Genetical analysis of examinations results.
ABSTRACT
1. Examination results for 98 pairs of same-sex and 39 pairs of opposite-sex twins were available for analysis as well as measurements of IQ and height for 47 of the same sex pairs. 2. The choice of subjects taken for examination is not influenced by genetic differences within DZ pairs but seems to be mainly determined by between family cultural differences. 3. Neither the sex difference in opposite-sex pairs nor the difference between first and second born twins in same-sex pairs contributes appreciably to within pair environmental variance. However, same-sex DZ pairs are more often found in different school classes than MZ pairs. 4. No evidence for interaction between genotypes and within-family environments was found for any character. 5. The simple environmental model fails to fit the data for English, French, Geography, Mathematics and IQ whereas the simple genetical model fits. For the remaining subjects it is not possible to exclude either hypothesis. The heritablities of the examination performances are of the same magnitude as that for IQ. 6. Sampling inadequacies are revealed in the data for height but there is evidence for a substantial genetics component of phenotype variation. 7. There is evidence for heterogeneity of gene action in the subjects English and Mathematics supporting the view that there are genetically determined specific abilities acting independently of general intelligence.
DATE PUBLISHED
1975 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1975/10/01
medline 1975/10/01 00:01
entrez 1975/10/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 39
ISSUE: 2
TITLE: Annals of human genetics
ISOABBREVIATION: Ann Hum Genet
YEAR: 1975
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0003-4800
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Ann Hum Genet
COUNTRY: England
ISSNLINKING: 0003-4800
NLMUNIQUEID: 0416661
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Age Factors
Analysis of Variance
Educational Measurement
Female
Humans
Intelligence
Language
Male
Mathematics
Pregnancy
Sex Factors
Twins
Twins, Dizygotic
Twins, Monozygotic
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's