Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
10405086
TITLE
Genetic influences on post-natal depressive symptoms: findings from an Australian twin sample.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Conflicting evidence exists on causes of vulnerability to post-natal depression. We investigated genetic and environmental influences on variation in post-natal depressive symptoms (PNDS) following first live birth, and sources of covariation with the personality trait Neuroticism and lifetime major depression occurring post-natally (DEP-PN) and at other times (DEP-XPN) to test for shared genetic influences.
METHOD NlmCategory: METHODS
Retrospective interview and questionnaire data from 838 parous female twin pairs (539 monozygotic, 299 dizygotic) from the Australian National Health and Medical Research Council volunteer adult twin register were used for multivariate genetic model-fitting. Data on PNDS were evaluated for consistency with diagnostic interview assessment.
RESULTS NlmCategory: RESULTS
Genetic factors explained 38% of variance in PNDS (95% confidence interval 26-49%) and 25% of the variance in interview-assessed DEP-PN. The genetic correlation between PNDS and lifetime major depression (DEP-PN and DEP-XPN) was low (r(g) = 0.17, 95% confidence interval = 0.09-0.28), suggesting that the questionnaire was measuring a construct other than postnatally occurring major depression, possibly post-natal dysphoria. Associations between PNDS and obstetric factors were very modest.
CONCLUSIONS NlmCategory: CONCLUSIONS
Findings suggest modest genetic influences on major depression occurring postnatally. Independent and stronger genetic influences identified for post-natal symptomatology or dysphoria (PNDS) justify further investigation.
DATE PUBLISHED
1999 May
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1999/07/15
medline 1999/07/15 00:01
entrez 1999/07/15 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Treloar SA Treloar S A SA Queensland Institute of Medical Research, Brisbane, Australia.
Martin NG Martin N G NG
Bucholz KK Bucholz K K KK
Madden PA Madden P A PA
Heath AC Heath A C AC
INVESTIGATORS
JOURNAL
VOLUME: 29
ISSUE: 3
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 1999
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0033-2917
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Depression, Postpartum psychology
Depressive Disorder, Major psychology
Female psychology
Follow-Up Studies psychology
Genetic Variation genetics
Humans genetics
Phenotype genetics
Psychiatric Status Rating Scales genetics
Questionnaires genetics
Retrospective Studies genetics
Twins psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's