Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
10392802
TITLE
Some implications of chaos theory for the genetic analysis of human development and variation.
ABSTRACT
Non-linear epigenetic processes are a potential underlying source of phenotypic differences in development. Simulation studies of twin pairs using simple non-linear development models characterised by chaotic or near-chaotic behavior are presented. The effect of chaotic processes on correlations is to lower them from their initial values, but high initial correlations are affected much less by chaotic and near-chaotic processes than intermediate correlations. Therefore, we would predict that traits affected by chaotic processes would have high MZ and low DZ twin correlations and this is reminiscent of certain traits such as EEG spectra. However the much more frequent observation of MZ correlations close to twice their DZ counterparts would suggest that the role of chaos in development is quite limited.
DATE PUBLISHED
1999 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1999/07/07
medline 1999/07/07 00:01
entrez 1999/07/07 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Eaves LJ Eaves L J LJ Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, USA.
Kirk KM Kirk K M KM
Martin NG Martin N G NG
Russell RJ Russell R J RJ
INVESTIGATORS
JOURNAL
VOLUME: 2
ISSUE: 1
TITLE: Twin research : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res
YEAR: 1999
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1369-0523
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res
COUNTRY: Australia
ISSNLINKING: 1369-0523
NLMUNIQUEID: 9815819
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
CommentIn Twin Res. 1999 Mar;2(1):49-52 10392803
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Computer Simulation
Electroencephalography
Genetic Variation genetics
Human Development genetics
Humans genetics
Logistic Models genetics
Models, Genetic genetics
Nonlinear Dynamics genetics
Phenotype genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's