Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
10203663
TITLE
Predictors of hysterectomy: an Australian study.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
We evaluated the relative importance of predictors of hysterectomy.
STUDY DESIGN NlmCategory: METHODS
A questionnaire survey of an Australia-wide sample of adult female twins was conducted; self-report data were validated against reports from treating physicians.
RESULTS NlmCategory: RESULTS
A total of 3096 women (94%) and 366 physicians (87%) responded. The sensitivity of patient report of hysterectomy was 98.2%. Best predictors of hysterectomy were endometriosis (odds ratio 4.85, 95% confidence interval 3.17-7.43), medical consultation for menorrhagia (odds ratio 3.55, 95% confidence interval 2.47-5.12), joint effects of fibroids with medical consultation for chronic or persisting pelvic pain (odds ratio 3.34, 95% confidence interval 1. 42 to 7.87), having smoked >40 cigarettes per day (odds ratio 3.24, 95% confidence interval 1.10-9.55), joint effects of fibroids with consultation for menstrual problems (odds ratio 2.61, 95% confidence interval 1.36-5.01), and tubal ligation (odds ratio 1.77, 95% confidence interval 1.31-2.39). Less-important predictors were age and higher education level (protective).
CONCLUSION NlmCategory: CONCLUSIONS
Consulting a physician about pelvic pain and menstrual problems, especially heavy bleeding, are recognized steps toward hysterectomy. Of particular interest for future genetic analyses are the high odds of hysterectomy for women with endometriosis, fibroids, or menorrhagia.
DATE PUBLISHED
1999 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1999/04/16
medline 1999/04/16 00:01
entrez 1999/04/16 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Treloar SA Treloar S A SA Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Queensland Institute of Medical Research, University of Queensland, Australia.
Do KA Do K A KA
O'Connor VM O'Connor V M VM
O'Connor DT O'Connor D T DT
Yeo MA Yeo M A MA
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 180
ISSUE: 4
TITLE: American journal of obstetrics and gynecology
ISOABBREVIATION: Am. J. Obstet. Gynecol.
YEAR: 1999
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0002-9378
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Obstet Gynecol
COUNTRY: UNITED STATES
ISSNLINKING: 0002-9378
NLMUNIQUEID: 0370476
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Distribution
Aged
Aged, 80 and over
Australia epidemiology
Confidence Intervals epidemiology
Endometriosis surgery
Female surgery
Humans surgery
Hysterectomy statistics & numerical data
Leiomyoma surgery
Menorrhagia surgery
Middle Aged surgery
Odds Ratio surgery
Ovariectomy statistics & numerical data
Pelvic Pain surgery
Prevalence surgery
Questionnaires surgery
Risk Factors surgery
Sensitivity and Specificity surgery
Uterine Neoplasms surgery
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's