|
|
| PMID |
|
|
| TITLE |
|
| Genetic influences on endometriosis in an Australian twin sample. sueT@qimr.edu.au. |
|
| ABSTRACT |
|
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| To investigate the prevalence of and twin pair concordance for endometriosis. |
| DESIGN |
NlmCategory: METHODS |
| A questionnaire survey incorporating validation. |
| SETTING |
NlmCategory: METHODS |
| An Australia-wide volunteer sample of female monozygotic (MZ) and dizygotic (DZ) twin pairs from the Australian National Health and Medical Research Council Twin Register. |
| PATIENT(S) |
NlmCategory: METHODS |
| Twins were selected only on the basis of previous participation in twin research. |
| INTERVENTION(S) |
NlmCategory: METHODS |
| Questionnaires were sent to 3,298 individuals. Information was requested from physicians named by consenting twins. |
| MAIN OUTCOME MEASURE(S) |
NlmCategory: METHODS |
| Reported endometriosis, validated where possible by pathology or surgical report. |
| RESULT(S) |
NlmCategory: RESULTS |
| Three thousand ninety-six (94%) of the twins and 145 (82%) of the physicians responded to the survey. Two hundred fifteen twins reported endometriosis, for a prevalence rate of .07 among question respondents. Tetrachoric twin pair correlations for self-reported endometriosis (MZ: n = 854 and DZ: n = 493) were rMz = .46+/-.09 and rDz = .28 +/-.13. When available medical and pathology reports were included, they changed to rMz =.52 +/-.08 and rDZ = .19+/-.16, suggesting that 51% of the variance of the latent liability to endometriosis may be attributable to additive genetic influences. |
| CONCLUSION(S) |
NlmCategory: CONCLUSIONS |
| These findings support the hypothesis that genes influence liability to endometriosis. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1999/04/15 |
| medline |
1999/04/15 00:01 |
| entrez |
1999/04/15 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Treloar SA |
|
Treloar |
S A |
SA |
|
Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Queensland Institute of Medical Research, Brisbane, Australia. sueT@qimr.edu.au |
| O'Connor DT |
|
O'Connor |
D T |
DT |
|
|
| O'Connor VM |
|
O'Connor |
V M |
VM |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 71 |
| ISSUE: 4 |
| TITLE: Fertility and sterility |
| ISOABBREVIATION: Fertil. Steril. |
| YEAR: 1999 |
| MONTH: Apr |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0015-0282 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Fertil Steril |
| COUNTRY: United States |
| ISSNLINKING: 0015-0282 |
| NLMUNIQUEID: 0372772 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
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| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Australia |
|
| Diseases in Twins |
|
| Endometriosis |
pathology |
| Female |
pathology |
| Humans |
pathology |
| Male |
pathology |
| Middle Aged |
pathology |
| Models, Genetic |
pathology |
| Phenotype |
pathology |
| Questionnaires |
pathology |
| Risk Factors |
pathology |
| Twins, Dizygotic |
pathology |
| Twins, Monozygotic |
pathology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
|
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|
