Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
10202882
TITLE
Genetic influences on endometriosis in an Australian twin sample. sueT@qimr.edu.au.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
To investigate the prevalence of and twin pair concordance for endometriosis.
DESIGN NlmCategory: METHODS
A questionnaire survey incorporating validation.
SETTING NlmCategory: METHODS
An Australia-wide volunteer sample of female monozygotic (MZ) and dizygotic (DZ) twin pairs from the Australian National Health and Medical Research Council Twin Register.
PATIENT(S) NlmCategory: METHODS
Twins were selected only on the basis of previous participation in twin research.
INTERVENTION(S) NlmCategory: METHODS
Questionnaires were sent to 3,298 individuals. Information was requested from physicians named by consenting twins.
MAIN OUTCOME MEASURE(S) NlmCategory: METHODS
Reported endometriosis, validated where possible by pathology or surgical report.
RESULT(S) NlmCategory: RESULTS
Three thousand ninety-six (94%) of the twins and 145 (82%) of the physicians responded to the survey. Two hundred fifteen twins reported endometriosis, for a prevalence rate of .07 among question respondents. Tetrachoric twin pair correlations for self-reported endometriosis (MZ: n = 854 and DZ: n = 493) were rMz = .46+/-.09 and rDz = .28 +/-.13. When available medical and pathology reports were included, they changed to rMz =.52 +/-.08 and rDZ = .19+/-.16, suggesting that 51% of the variance of the latent liability to endometriosis may be attributable to additive genetic influences.
CONCLUSION(S) NlmCategory: CONCLUSIONS
These findings support the hypothesis that genes influence liability to endometriosis.
DATE PUBLISHED
1999 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1999/04/15
medline 1999/04/15 00:01
entrez 1999/04/15 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Treloar SA Treloar S A SA Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Queensland Institute of Medical Research, Brisbane, Australia. sueT@qimr.edu.au
O'Connor DT O'Connor D T DT
O'Connor VM O'Connor V M VM
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 71
ISSUE: 4
TITLE: Fertility and sterility
ISOABBREVIATION: Fertil. Steril.
YEAR: 1999
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0015-0282
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Fertil Steril
COUNTRY: United States
ISSNLINKING: 0015-0282
NLMUNIQUEID: 0372772
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Australia
Diseases in Twins
Endometriosis pathology
Female pathology
Humans pathology
Male pathology
Middle Aged pathology
Models, Genetic pathology
Phenotype pathology
Questionnaires pathology
Risk Factors pathology
Twins, Dizygotic pathology
Twins, Monozygotic pathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's