Examples for Sib-pair
I have prepared Sib-pair style pedigree and script files for a number of
published datasets from the genetics literature. More extensive
documentation is to be found in the comments at the head of the
each script and pedigree file, often including results obtained by using
other genetics packages. Several are well-known examples that have been
analysed by several authors.
alopecia.in, alopecia.ped
Interesting inbred pedigree used to map Alopecia Universalis by
Ahmad et al (Science 1998; 279: 720-4).
apoa.in, apoa.ped
Plasma Apo(a) genotypes, Apo(a) isoforms, and Lp(a) levels,
in 52 African-American families from Mooser et al AJHG 61: 402-17.
ataxia.in, ataxia.ped
Episodic Ataxia/Myokymia pedigrees from Litt et al AJHG 1994; 55: 702-9
used as an example for APM mapping by Davis et al. AJHG 1996; 58: 867-80.
blau.in, blau.ped
Blau family syndrome pedigree from Tromp et al AJHG 1996; 59: 1097-1107
breast.in, breast.ped
Breast Ca pedigrees from Hall et al Science 1990; 250: 1684-9.
cai.in, cai.ped
The large pedigree with cosegregation of Alzheimers disease and APOE
from Cai et al Am J Med Genet (Neuropsychiatr Genet) 1997; 74: 365-69.
davie.in, davie.ped
PKU sibships as an example of estimating segregation ratios under
incomplete ascertainment from Davie Ann Hum Genet 1979; 42: 507-11.
devries.in, devries.ped
HLA data from DeVries et al , used as an example by Lange 1988.
epilepsy.in, epilepsy.ped
Idiopathic generalized epilepsy -- Zara et al (Hum Mol Genet 1995; 4:1201-7).
Reanalysed by Kruglyak & Lander (AJHG 1996 58:1347-63).
errors.in, errors.ped
Two pedigrees with Mendelian incompatibilities from Stringham & Boehnke
AJHG 1996; 59: 946-50.
fmf.in, fmf.ped
Familial Mediterranean Fever mapping families from Shohat et al AJHG 1992;
51: 1349-54.
ghex.in, ghex.ped
Genehunter example with two large sibships, 11 markers each 9.1% apart.
hlp3.in, hlp3.ped
Pedigrees from Feussner et al. Genetics of Type III hyperlipoproteinemia.
Genet Epidemiol 14: 283-97
lgmd2a.in, lgmd2a.ped
Limb-Girdle Muscular Dystrophy Type 2A -- Chrom 15 CANP3 from
Richard et al Am J Hum Genet 1997; 60: 1128-1138.
lincl.in, lincl.ped
Finnish families containing probands suffering from neuronal ceroid
lipofuscinosis described in Savukoski et al AJHG 1994; 55: 695-701.
nem1.in, nem1.ped
Nemaline Myopathy pedigree from Laing et al AJHG 1992; 50:576-83.
NEM, ApoC2, as per Fig 1.
psoriasis.in, psoriasis.ped
Psoriasis families from Matthews et al Nat Genet 1996; 14: 231-3
8 chromosome 4q markers from genome scan.
rossen.in, rossen.ped
HLA-DR sharing in a rheumatoid arthritis pedigree from Rossen et al
Hum Immunol 1982; 4:183-196 used as an example of IBD-APM methods by
Whittemore & Halpern Biometrics 1994; 50: 118-127.
userex7.in, userex7.ped
Example 7 from Terwilliger & Ott, Handbook of Human Genetic Linkage --
consanguinuity loops incl double first cousin marriage.
ward.in, ward.ped
Analysis of Patrick Ward's example pedigree AJHG 1993.
volga.in, volga.ped
Volga German AD families from Schellenberg et al Science 1992; 258:668-71.
williams.in, williams.ped
Family 26 from hypercholesterolemia study of Williams et al JAMA 1986
used to establish linkage to LDL-R RFLP in Leppert et al
Am J Hum Genet 1986; 39: 300-6 and reanalysed by several authors
eg Guo & Thompson AJHG 1992; 51:1111-26
zieve.in, zieve.ped
Atopy data from Zieve et al Ann Eugenics 1937; 163-78.