! ! Episodic Ataxia/Myokymia pedigrees from Litt et al AJHG 1994; 55: 702-9 ! used as an example for APM mapping by Davis et al. AJHG 1996; 58: 867-80 ! 10 C12 markers ! ! pY21/1 == D12S1088 ! ! pter--S91 S100 CACNL1A1 S372 pY2/1 pY21/1 KCNA5 S93 S99--cen ! 1.0 1.0 3.0 ------ 3.0 ------ 1.0 1.0 ! ! multipoint LOD score analysis gives Zmax=11.35 between D12S99 and KCNA5 ! set impute on set datadir ../pedigrees set locus ep_ataxia aff set locus D12S91 marker 1.03 817436 set locus D12S100 marker 4.76 2046844 set locus CACNL1A1 marker 5.00 2556212 set locus D12S372 marker 6.42 3457623 set locus pY2/1 marker 14.6 set locus pY21/1 marker 14.7 4801018 set locus KCNA5 marker 14.8 5024750 set locus D12S93 marker 15.0 5201115 set locus D12S99 marker 15.2 5434861 read pedigree inline 4 2002 x x m n 1 1 1 4 9 10 2 2 1 5 5 7 3 4 4 7 4 6 4 2001 x x f n x x x x x x x x x x x x x x x x x x 4 1001 x x m n 1 3 3 3 9 9 4 5 6 6 3 4 3 4 6 6 1 5 4 1000 2002 2001 f y 1 3 4 6 10 10 2 3 1 2 7 7 2 3 4 7 3 6 4 1002 2002 2001 m n 1 2 4 5 10 10 2 2 1 1 7 10 3 4 4 7 5 6 4 1006 2002 2001 f y 1 3 4 6 10 10 2 3 1 2 7 7 2 3 4 7 3 6 4 1007 x x m n 3 3 4 6 1 8 2 3 x x 4 7 2 4 3 4 3 6 4 1008 2002 2001 f y 1 3 1 6 9 10 2 3 2 5 5 7 2 4 4 4 3 4 4 1009 x x m n 1 2 3 3 2 9 2 3 1 1 4 5 1 2 1 1 2 5 4 1010 2002 2001 f y 1 3 1 6 9 10 2 3 2 5 5 7 2 4 4 4 3 4 4 1011 x x m n x x x x x x x x x x x x x x x x x x 4 100 1001 1000 m n 1 1 3 4 9 10 2 5 1 6 4 7 3 3 6 7 1 6 4 102 1001 1000 m y 3 3 3 6 9 10 3 4 2 6 4 7 2 4 4 6 3 5 4 103 x x f n 1 2 2 3 10 10 3 4 6 6 3 4 1 3 x x 4 6 4 1 1001 1000 m y 1 3 3 6 9 10 3 5 2 6 3 7 2 3 4 6 1 3 4 104 x x f n 1 4 3 4 9 9 2 3 6 6 5 10 1 1 3 6 7 8 4 114 1007 1006 f y 3 3 6 6 8 10 3 3 2 6 4 7 2 2 4 4 3 3 4 113 1007 1006 f y 3 3 4 6 1 10 2 3 1 6 4 7 2 3 4 7 3 6 4 115 1009 1008 m y 1 3 3 6 9 10 2 3 1 2 4 7 2 2 1 4 3 5 4 116 1011 1010 m y 3 3 2 6 9 10 3 3 1 2 4 7 1 2 4 4 3 4 4 117 x x f n 1 3 1 4 8 9 2 3 5 6 5 5 4 4 4 4 4 4 4 9003 102 103 m y 2 3 2 6 10 10 3 4 2 6 4 7 2 3 4 6 3 4 4 9004 102 103 m n 1 3 3 6 10 10 3 3 6 6 3 4 1 4 4 6 5 6 4 9005 1 104 f y 1 3 4 6 9 10 3 3 2 6 5 7 1 2 x x 3 7 4 9006 1 104 m x 1 1 3 4 9 9 3 5 6 6 3 5 1 3 x x x x 3 101 x x m y x x x x x x x x x x x x x x x x x x 3 102 x x f n x x x x x x x x x x x x x x x x x x 3 2082 x x f n x x x x x x x x x x x x x x x x x x 3 208 101 102 m y x x x x x x x x x x x x x x x x x x 3 205 101 102 f y x x x x x x x x x x x x x x x x x x 3 2051 x x m n x x x x x x x x x x x x x x x x x x 3 3332 x x f n x x 2 5 9 10 1 2 3 6 2 3 4 6 1 3 1 6 3 333 208 2082 m y x x x x x x x x x x x x x x x x x x 3 341 208 2082 m n x x 3 3 9 9 3 3 3 6 3 4 3 6 2 3 6 7 3 339 208 2082 f n x x 2 3 9 9 2 3 2 6 4 6 3 6 2 3 6 7 3 336 208 2082 f n x x 2 3 9 9 2 3 2 3 4 6 3 3 3 3 7 8 3 331 208 2082 f y x x 3 3 9 9 2 3 3 3 3 4 3 3 1 3 7 8 3 332 208 2082 f y x x x x x x x x x x x x x x x x x x 3 3321 x x m n x x x x x x x x x x x x x x x x x x 3 334 208 2082 f y x x 3 3 9 9 3 3 3 6 x x 3 6 1 2 6 7 3 3341 x x m n x x x x x x x x x x x x x x x x x x 3 335 208 2082 m y x x 3 3 9 9 3 3 3 6 3 4 3 6 1 2 6 7 3 3352 x x f n x x 2 2 9 10 4 5 3 4 3 4 4 6 1 2 3 4 3 322 2051 205 m n x x 3 5 8 9 4 4 2 2 3 6 3 6 2 3 2 7 3 323 2051 205 f n x x 3 5 8 9 4 4 2 2 3 6 3 4 2 3 2 7 3 325 2051 205 f y x x 2 3 9 9 3 4 3 3 3 3 3 4 1 2 6 7 3 326 2051 205 f y x x 3 5 9 9 3 4 2 3 3 3 3 6 1 2 2 7 3 324 2051 205 m y x x x x x x x x x x x x x x x x x x 3 3242 x x f n x x x x x x x x x x x x x x x x x x 3 4171 x x m n x x 3 5 9 9 2 4 1 4 3 3 4 4 1 2 1 6 3 417 333 3332 f y x x 2 3 9 9 2 3 3 6 2 3 3 6 1 3 6 7 3 418 333 3332 m n x x 2 3 9 9 2 3 6 6 2 4 6 6 2 3 6 6 3 416 333 3332 m n x x 2 3 9 9 2 3 6 6 2 4 6 6 2 3 6 6 3 415 333 3332 f y x x 3 5 9 10 1 3 3 3 3 3 x x 1 1 1 7 3 4151 x x m n x x 2 2 9 9 4 4 2 3 3 6 x x 1 2 6 8 3 414 3321 332 f y x x 2 3 7 9 4 4 3 7 2 3 x x 1 2 4 7 3 411 3321 332 f n x x 2 3 9 9 3 4 3 6 4 4 4 6 1 2 6 8 3 412 3321 332 f y x x 2 3 9 9 3 4 3 7 2 3 x x 1 2 4 7 3 4121 x x m n x x 2 2 9 10 3 4 2 7 2 4 x x 2 2 3 5 3 420 3341 334 m n x x 1 3 9 12 3 3 5 6 4 4 4 6 2 5 6 7 3 419 3341 334 f n x x 1 3 9 12 3 3 5 6 4 4 4 6 2 5 6 7 3 4211 x x m n x x 1 2 8 9 4 5 2 7 2 4 x x 2 3 6 8 3 421 335 3352 f y x x 2 3 9 9 3 5 3 4 3 3 3 6 1 1 4 7 3 423 335 3352 m n x x 2 3 9 9 3 5 4 6 3 4 6 6 1 2 4 6 3 422 335 3352 f y x x 2 3 9 9 3 5 3 4 3 3 3 6 1 1 4 7 3 4221 x x m n x x 3 3 8 12 1 4 3 3 2 3 6 6 1 3 6 7 3 410 324 3242 f n x x 2 2 9 9 1 4 3 6 1 3 3 4 2 2 5 6 3 409 324 3242 m y x x 2 3 9 9 1 3 3 6 1 3 3 3 1 2 5 7 3 4092 x x f n x x 2 4 9 9 2 4 3 4 4 10 3 6 2 4 3 5 3 512 4171 417 f n x x 2 5 9 9 2 2 4 6 2 3 4 6 2 3 6 6 3 511 4151 415 f y x x 2 3 9 9 3 4 2 3 3 6 3 4 1 2 7 8 3 510 4151 415 f n x x 2 5 9 10 1 4 2 3 3 6 4 4 1 2 1 8 3 504 4121 412 m n x x 2 2 9 9 3 4 7 7 2 2 6 6 2 2 4 5 3 503 4121 412 f y x x 2 3 9 10 3 4 2 3 3 4 3 4 2 1 3 7 3 513 4211 421 m y x x 2 3 8 9 3 4 2 3 3 4 3 4 1 3 6 7 3 514 4211 421 f n x x 1 2 9 9 5 5 4 7 2 3 6 6 1 2 4 8 3 516 4221 422 f n x x 2 3 8 9 4 5 3 4 2 3 6 6 1 1 4 7 3 515 4221 422 m y x x 2 3 9 12 1 5 3 3 3 3 3 6 1 3 6 7 3 501 409 4092 f y x x 2 2 9 9 1 4 3 3 3 10 3 3 1 4 3 7 ;;;; run apm ep_ataxia ibd tdt ep_ataxia assoc ep_ataxia sibpair ep_ataxia