Linkage and Association

David L. Duffy, MBBS PhD.
QIMR Berghofer Medical Research Institute,
300 Herston Road,
Herston, Queensland 4029, Australia.
Email: davidD@qimr.edu.au

LECTURE MATERIALS

• Introduction to Genetic Epidemiology
• Introduction to Genetic Linkage
• Introduction to Biometrical Genetics
• Introduction to Allelic Association and GWAS
• Using computer simulation in genetic analysis
• Running MERLIN
• Running MENDEL
• Working through a GWAS with Sib-pair and PLINK
• Haplotyping samples of unrelated individuals
• An example of followup in a two-stage GWAS

EXERCISES

• Quantitative genetics of sACE
• Nonparametric linkage and familial association analysis
• Finding the gene for blue eyes
• Analysing Genome Wide Association Studies

SUPPLEMENTARY MATERIALS

• Elementary population genetics for genetic epidemiology
• Using SOLAR to analyze a classical twin study
• A short survey of useful programs for genetic analysis
• Overview of necessary background

PROGRAM DOCUMENTATION

• Merlin quick reference
• PLINK quick reference
• FBAT manual
• Introduction to Sib-pair
• Sib-pair manual

PAPERS

• Abreu_simplelods1999.pdf
• Duffy_asthma1998.pdf
• Duffy_OCA2SNPeyecolour2006.pdf
• Kammerer_ACElinkage2004.pdf
• Keavney_ACEhaplotypes1998.pdf
• Lange_MENDELassoc2005.pdf
• McGuffinHuckle_medschoolgene1990.pdf
• Sturm_EyeColour2008.pdf
• Wang_AmishBPGWAS2008.pdf
• Simpson_ELP3andALS2009.pdf