| Class | Global Utility |
| Name | grr |
| Arguments | <trait prevalence> <Frequency of A allele> <genotypic risk ratio> [add|dom|rec] |
| <trait prevalence> <Frequency of A allele in cases> <Frequency of A allele in controls> case-control |
Calculates recurrence risks and segregation ratios under a diallelic generalized single major locus model specified via trait prevalence, ratio of penetrances and pattern of inheritance (codominant multiplicative, dominant or recessive).
If the case-control modifier is present, instead it expects the prevalence, risk allele frequency in cases, and risk allele frequency in controls who can either be unaffected, or of unknown status (population).
See sml for interpretation of the output.
Example:
>> grr 0.1 0.1 { 1.5 2 2.5 }
>> grr 0.1 0.2 0.1 case
------------------------------------------------
Single Major Locus Recurrence Risk Calculation
------------------------------------------------
Frequency(A): 0.110000; Pen(AA): 0.331; Pen(AB): 0.163; Pen(BB): 0.081
Trait Prev : 0.100000; Pop AR: 19.2%; Var(Add): 0.001655; Var(Dom): 0.000068
Measure MZ Twin Sib-Sib Par-Off Second
---------- ---------- ---------- --------- ----------
Rec risk 0.117 0.108 0.108 0.104
Rel risk 1.195 1.095 1.093 1.046
Odds rat 1.221 1.106 1.104 1.052
PRR 1.172 1.084 1.083 1.041
ibd|A-A 1.000 0.520 0.500 0.260
ibd|A-U 1.000 0.498 0.500 0.249
Freq of A if Affected: 0.200000 (0.040,0.320,0.640)
Freq of A if Unaffctd: 0.100000 (0.009,0.182,0.809)
Mating Proportion Risk to offspring
---------- ----------- ------------------
UnA x UnA 0.810 0.098
Aff x UnA 0.180 0.107
Aff x Aff 0.010 0.117
See also:
| sml | recurrence risks |
| << (sml) | Up to index | >> (ito) |