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| PMID |
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| TITLE |
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| Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls. |
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| ABSTRACT |
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| Mounting evidence suggests that individuals with schizophrenia have an underlying vulnerability to cardiovascular disease, and a recent study suggested that this vulnerability might be reflected in the retinal microvasculature. The purpose of this study was to test the hypothesis that the retinal microvessels reflect familial vulnerability to psychotic symptoms. Participants were 531 adolescent and young adult twins who took part in the Brisbane Longitudinal Twin Study and the Twins Eye Study in Tasmania. The twins had photographs taken of their retina when they were adolescents or young adults (M age=20.6 years), and retinal vessel diameter was assessed using computer software. The twins completed an assessment of psychosis symptoms approximately six years later. We compared retinal venular diameters of individuals with one or more symptoms of psychosis (n=45), their unaffected co-twins (n=24), and controls (n=462). Individuals with one or more symptoms of psychosis had wider venules (standardized mean=0.29) than controls (standardized mean=-0.04; p=.03), and unaffected co-twins had venular diameters that were intermediate (standardized mean=0.13) between the two groups, suggesting that wide venules may represent a proxy marker of familial vulnerability to psychosis symptoms. Consistent with previous work, there were no differences in arteriolar diameter between individuals with and without symptoms of psychosis. Findings suggest that wide retinal venules may serve as a proxy marker of familial liability to psychosis symptoms. The pathophysiological mechanisms linking psychosis and cardiovascular disease may be operative from early in life, possibly at the level of the microvasculature. |
| Copyright © 2015 Elsevier B.V. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2014/11/04 |
| revised |
2015/01/26 |
| accepted |
2015/01/29 |
| entrez |
2015/02/20 06:00 |
| pubmed |
2015/02/20 06:00 |
| medline |
2016/03/24 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Meier MH |
|
Meier |
Madeline H |
MH |
|
Department of Psychology, Arizona State University, Tempe, AZ, USA. Electronic address: madeline.meier@asu.edu. |
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA; QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Hansell NK |
|
Hansell |
Narelle K |
NK |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Hewitt AW |
|
Hewitt |
Alex W |
AW |
|
Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain and Mind Research Institute, University of Sydney, Sydney, Australia. |
| Lu Y |
|
Lu |
Yi |
Y |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| McGrath J |
|
McGrath |
John |
J |
|
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia; Queensland Brain Institute, University of Queensland, St Lucia, Australia. |
| MacGregor S |
|
MacGregor |
Stuart |
S |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Sun C |
|
Sun |
Cong |
C |
|
Environmental and Genetic Epidemiology Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia. |
| Wong TY |
|
Wong |
Tien Y |
TY |
|
Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Zhu G |
|
Zhu |
Gu |
G |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Mackey DA |
|
Mackey |
David A |
DA |
|
Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia. |
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| INVESTIGATORS |
|
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| JOURNAL |
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| VOLUME: 164 |
| ISSUE: 1-3 |
| TITLE: Schizophrenia research |
| ISOABBREVIATION: Schizophr Res |
| YEAR: 2015 |
| MONTH: May |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-2509 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Schizophr Res |
| COUNTRY: Netherlands |
| ISSNLINKING: 0920-9964 |
| NLMUNIQUEID: 8804207 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Comparative Study |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R00 DA023549 |
NIDA NIH HHS |
United States |
| DA023549 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Psychosis |
| Retinal vessel diameter |
| Twin |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Diagnosis, Computer-Assisted |
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| Family Health |
|
| Female |
|
| Humans |
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| Longitudinal Studies |
|
| Male |
|
| Psychiatric Status Rating Scales |
|
| Psychotic Disorders |
pathology |
| Retinal Vessels |
pathology |
| Young Adult |
pathology |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
|
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| OTHER ID's |
|
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|
