Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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25231870
TITLE
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
ABSTRACT
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition.
DATE PUBLISHED
2014 Oct 02
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/12/23
accepted 2014/05/30
entrez 2014/09/19 06:00
pubmed 2014/09/19 06:00
medline 2014/10/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Perry JR Perry John Rb JR Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Day F Day Felix F MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Elks CE Elks Cathy E CE MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Sulem P Sulem Patrick P deCODE Genetics, Reykjavik, Iceland.
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK.
Ferreira T Ferreira Teresa T Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
He C He Chunyan C Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, MA 02115.
Esko T Esko Tõnu T Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Thorleifsson G Thorleifsson Gudmar G deCODE Genetics, Reykjavik, Iceland.
Albrecht E Albrecht Eva E Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Ang WQ Ang Wei Q WQ School of Women's and Infants' Health, The University of Western Australia.
Corre T Corre Tanguy T Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Cousminer DL Cousminer Diana L DL Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.
Feenstra B Feenstra Bjarke B Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark.
Franceschini N Franceschini Nora N Department of Epidemiology, University of North Carolina, Chapel Hill, NC.
Ganna A Ganna Andrea A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Johnson AD Johnson Andrew D AD NHLBI's and Boston University's Framingham Heart Study, Framingham, MA.
Kjellqvist S Kjellqvist Sanela S Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Lunetta KL Lunetta Kathryn L KL Boston University School of Public Health, Department of Biostatistics. Boston, MA.
McMahon G McMahon George G School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Nolte IM Nolte Ilja M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Paternoster L Paternoster Lavinia L MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Porcu E Porcu Eleonora E University of Sassari, Dept. Of Biomedical Sciences, Sassari, Italy.
Smith AV Smith Albert V AV University of Iceland, Reykjavik, Iceland.
Stolk L Stolk Lisette L Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.
Teumer A Teumer Alexander A Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
Tšernikova N Tšernikova Natalia N Department of Biotechnology, University of Tartu, Tartu, 51010, Estonia.
Tikkanen E Tikkanen Emmi E Hjelt Institute, University of Helsinki, Finland.
Ulivi S Ulivi Sheila S Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste, Italy.
Wagner EK Wagner Erin K EK Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
Amin N Amin Najaf N Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Bierut LJ Bierut Laura J LJ Dept. of Psychiatry, Washington University, St. Louis, MO 63110.
Byrne EM Byrne Enda M EM QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Koller DL Koller Daniel L DL Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana USA.
Mangino M Mangino Massimo M Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Pers TH Pers Tune H TH Center for Biological Sequence Analysis, Department of Systems Biology, Technical 142 University of Denmark, Lyngby 2800, Denmark.
Yerges-Armstrong LM Yerges-Armstrong Laura M LM Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201.
Zhao JH Zhao Jing Hua JH MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Andrulis IL Andrulis Irene L IL Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Anton-Culver H Anton-Culver Hoda H Department of Epidemiology, University of California Irvine, Irvine, California, USA.
Atsma F Atsma Femke F Sanquin Research, Nijmegen, The Netherlands.
Bandinelli S Bandinelli Stefania S Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy.
Beckmann MW Beckmann Matthias W MW University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Benitez J Benitez Javier J Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
Blomqvist C Blomqvist Carl C Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Bojesen SE Bojesen Stig E SE Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Bolla MK Bolla Manjeet K MK Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK.
Bonanni B Bonanni Bernardo B Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
Brauch H Brauch Hiltrud H University of Tübingen, Germany.
Brenner H Brenner Hermann H German Cancer Consortium (DKTK), Heidelberg, Germany.
Buring JE Buring Julie E JE Harvard Medical School, Boston, MA 02115.
Chang-Claude J Chang-Claude Jenny J Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Chanock S Chanock Stephen S Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Chen J Chen Jinhui J Stark Neuroscience Research Center, Indiana University school of Medicine, Indianapolis, IN 46202, USA.
Chenevix-Trench G Chenevix-Trench Georgia G Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Collée JM Collée J Margriet JM Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Couch FJ Couch Fergus J FJ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Couper D Couper David D Department of Biostatistics, University of North Carolina, Chapel Hill, NC.
Coveillo AD Coveillo Andrea D AD Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, MA.
Cox A Cox Angela A Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK.
Czene K Czene Kamila K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
D'adamo AP D'adamo Adamo Pio AP Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Italy.
Smith GD Smith George Davey GD School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
De Vivo I De Vivo Immaculata I Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Demerath EW Demerath Ellen W EW Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minn., USA.
Dennis J Dennis Joe J Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK.
Devilee P Devilee Peter P Department of Human Genetics & Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Dieffenbach AK Dieffenbach Aida K AK German Cancer Consortium (DKTK), Heidelberg, Germany.
Dunning AM Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK.
Eiriksdottir G Eiriksdottir Gudny G Icelandic Heart Association, Kopavogur, Iceland.
Eriksson JG Eriksson Johan G JG Folkhalsan Research Centre, Helsinki, Finland.
Fasching PA Fasching Peter A PA University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Ferrucci L Ferrucci Luigi L Longitudinal Studies Section, Clinical Research Branch, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, United States of America.
Flesch-Janys D Flesch-Janys Dieter D Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Flyger H Flyger Henrik H Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Foroud T Foroud Tatiana T Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana USA.
Franke L Franke Lude L Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Garcia ME Garcia Melissa E ME National Insitute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
García-Closas M García-Closas Montserrat M Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
Geller F Geller Frank F Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark.
de Geus EE de Geus Eco Ej EE EMGO + Institute for Health and Care Research, VU University Medical Centre, Van der Boechorststraat 7, 1081 Bt, Amsterdam, The Netherlands.
Giles GG Giles Graham G GG Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Gudbjartsson DF Gudbjartsson Daniel F DF Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Gudnason V Gudnason Vilmundur V University of Iceland, Reykjavik, Iceland.
Guénel P Guénel Pascal P University Paris-Sud, UMRS 1018, Villejuif, France.
Guo S Guo Suiqun S Department of Obstetrics and Gynecology, Southern Medical University, Guangzhou, China.
Hall P Hall Per P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Hamann U Hamann Ute U Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Haring R Haring Robin R Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Hartman CA Hartman Catharina A CA Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Heath AC Heath Andrew C AC Washington University, Department of Psychiatry, St.Louis, Missouri, USA.
Hofman A Hofman Albert A Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands.
Hooning MJ Hooning Maartje J MJ Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hopper JL Hopper John L JL Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Hu FB Hu Frank B FB Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Hunter DJ Hunter David J DJ Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Karasik D Karasik David D Hebrew SeniorLife Institute for Aging Research, Boston, MA.
Kiel DP Kiel Douglas P DP Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115.
Knight JA Knight Julia A JA Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Kosma VM Kosma Veli-Matti VM Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Kutalik Z Kutalik Zoltan Z Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Lai S Lai Sandra S Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Lambrechts D Lambrechts Diether D Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
Lindblom A Lindblom Annika A Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Mägi R Mägi Reedik R Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Magnusson PK Magnusson Patrik K PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Mannermaa A Mannermaa Arto A Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Martin NG Martin Nicholas G NG Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Masson G Masson Gisli G deCODE Genetics, Reykjavik, Iceland.
McArdle PF McArdle Patrick F PF Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201.
McArdle WL McArdle Wendy L WL School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Melbye M Melbye Mads M Department of Medicine, Stanford School of Medicine, Stanford, USA.
Michailidou K Michailidou Kyriaki K Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK.
Mihailov E Mihailov Evelin E Department of Biotechnology, University of Tartu, Tartu, 51010, Estonia.
Milani L Milani Lili L Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Milne RL Milne Roger L RL Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Nevanlinna H Nevanlinna Heli H Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Neven P Neven Patrick P KULeuven (University of Leuven), Department of Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, Belgium.
Nohr EA Nohr Ellen A EA Research Unit of Obstetrics & Gynecology, Institute of Clinical Research, University of Southern denmark, DK.
Oldehinkel AJ Oldehinkel Albertine J AJ Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Oostra BA Oostra Ben A BA Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
Palotie A Palotie Aarno A Psychiatric & Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Peacock M Peacock Munro M Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana USA.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Peterlongo P Peterlongo Paolo P IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
Peto J Peto Julian J Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Pharoah PD Pharoah Paul Dp PD Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK.
Postma DS Postma Dirkje S DS University Groningen, University Medical Center Groningen, Department Pulmonary Medicine and Tuberculosis, GRIAC Research Institute, Groningen, The Netherlands.
Pouta A Pouta Anneli A Department of Obstetrics and Gynecology, Oulu University Hospital, Finland.
Pylkäs K Pylkäs Katri K Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital/NordLab Oulu, Oulu, Finland.
Radice P Radice Paolo P Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
Ring S Ring Susan S School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Rivadeneira F Rivadeneira Fernando F Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands.
Robino A Robino Antonietta A Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Italy.
Rose LM Rose Lynda M LM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.
Rudolph A Rudolph Anja A Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Salomaa V Salomaa Veikko V National Institute for Health and Welfare, Finland.
Sanna S Sanna Serena S Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Schlessinger D Schlessinger David D National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Schmidt MK Schmidt Marjanka K MK Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Southey MC Southey Mellissa C MC Department of Pathology, The University of Melbourne, Melbourne, Australia.
Sovio U Sovio Ulla U Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, United Kingdom.
Stampfer MJ Stampfer Meir J MJ Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Stöckl D Stöckl Doris D Department of Obstetrics and Gynaecology, Campus Grosshadern, Ludwig-Maximilians- University, Munich, Germany.
Storniolo AM Storniolo Anna M AM Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana USA.
Timpson NJ Timpson Nicholas J NJ School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Tyrer J Tyrer Jonathan J Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, UK.
Visser JA Visser Jenny A JA Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.
Vollenweider P Vollenweider Peter P Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Völzke H Völzke Henry H DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany.
Waeber G Waeber Gerard G Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Waldenberger M Waldenberger Melanie M Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Wallaschofski H Wallaschofski Henri H DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany.
Wang Q Wang Qin Q Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Winqvist R Winqvist Robert R Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, Oulu University Hospital/NordLab Oulu, Oulu, Finland.
Wolffenbuttel BH Wolffenbuttel Bruce Hr BH Department of Endocrinology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Wright MJ Wright Margaret J MJ Queensland Insitute of Medical Research, Brisbane, Queensland, Australia.
Australian Ovarian Cancer Study
GENICA Network
kConFab
LifeLines Cohort Study
InterAct Consortium
Early Growth Genetics (EGG) Consortium
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Econs MJ Econs Michael J MJ Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana USA.
Khaw KT Khaw Kay-Tee KT Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, CB2 0QQ, UK.
Loos RJ Loos Ruth Jf RJ Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1003, New York, NY 10029, USA.
McCarthy MI McCarthy Mark I MI Oxford Centre for Diabetes, Endocrinology, & Metabolism, University of Oxford, Churchill Hospital, OX37LJ Oxford, UK.
Montgomery GW Montgomery Grant W GW Queensland Insitute of Medical Research, Brisbane, Queensland, Australia.
Rice JP Rice John P JP Dept. of Psychiatry, Washington University, St. Louis, MO 63110.
Streeten EA Streeten Elizabeth A EA Geriatric Research and Education Clinical Center (GRECC) - Veterans Administration Medical Center, USA. Baltimore, MD 21201.
Thorsteinsdottir U Thorsteinsdottir Unnur U Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
van Duijn CM van Duijn Cornelia M CM Centre of Medical Systems Biology, Leiden, the Netherlands.
Alizadeh BZ Alizadeh Behrooz Z BZ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Bergmann S Bergmann Sven S Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Boerwinkle E Boerwinkle Eric E Human Genetics Center and Div. of Epidemiology, University of Houston, TX.
Boyd HA Boyd Heather A HA Department of Epidemiology Research, Statens Serum Institut, DK-2300 Copenhagen, Denmark.
Crisponi L Crisponi Laura L Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Gasparini P Gasparini Paolo P Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Italy.
Gieger C Gieger Christian C Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Harris TB Harris Tamara B TB National Insitute on Aging, National Institutes of Health, Baltimore, MD 20892, USA.
Ingelsson E Ingelsson Erik E Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Järvelin MR Järvelin Marjo-Riitta MR Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O.Box 20, FI-90220 Oulu, 90029 OYS, Finland.
Kraft P Kraft Peter P Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
Lawlor D Lawlor Debbie D School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Metspalu A Metspalu Andres A Department of Biotechnology, University of Tartu, Tartu, 51010, Estonia.
Pennell CE Pennell Craig E CE School of Women's and Infants' Health, The University of Western Australia.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, MA 02115.
Snieder H Snieder Harold H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Sørensen TI Sørensen Thorkild Ia TI Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, The Capital Region, Copenhagen, Denmark.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Strachan DP Strachan David P DP Division of Population Health Sciences and Education, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.
Uitterlinden AG Uitterlinden André G AG Department of Epidemiology, Erasmus MC, Rotterdan, the Netherlands.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Widen E Widen Elisabeth E Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland.
Zygmunt M Zygmunt Marek M Department of Obstetrics and Gynecology, University Medicine Greifswald, 17475 Greifswald, Germany.
Murray A Murray Anna A University of Exeter Medical School, University of Exeter, Exeter, UK EX1 2LU.
Easton DF Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, UK.
Stefansson K Stefansson Kari K Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Murabito JM Murabito Joanne M JM Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA.
Ong KK Ong Ken K KK Department of Paediatrics,University of Cambridge,Cambridge,UK.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Cousminer Diana L DL
Stergiakouli Evangelia E
Berry Diane J DJ
Ang Wei W
Groen-Blokhuis Maria M MM
Körner Antje A
Siitonen Niina N
Ntalla Ioanna I
Marinelli Marcella M
Perry John R B JR
Kettunen Johannes J
Jansen Rick R
Surakka Ida I
Timpson Nicholas J NJ
Ring Susan S
McMahon George G
Power Chris C
Wang Carol C
Kähönen Mika M
Viikari Jorma J
Lehtimäki Terho T
Middeldorp Christel M CM
Hulshoff Pol Hilleke E HE
Neef Madlen M
Weise Sebastian S
Pahkala Katja K
Niinikoski Harri H
Zeggini Eleftheria E
Panoutsopoulou Kalliope K
Bustamante Mariona M
Penninx Brenda W J H BW
Murabito Joanne J
Torrent Maties M
Dedoussis George V GV
Kiess Wieland W
Boomsma Dorret I DI
Pennell Craig E CE
Raitakari Olli T OT
Hyppönen Elina E
Davey Smith George G
Ripatti Samuli S
McCarthy Mark I MI
Widén Elisabeth E
Alizadeh Behrooz Z BZ
de Boer Rudolf A RA
Boezen H Marike HM
Bruinenberg Marcel M
Franke Lude L
van der Harst Pim P
Hillege Hans L HL
van der Klauw Melanie M MM
Navis Gerjan G
Ormel Johan J
Postma Dirkje S D
Rosmalen Judith G M JG
Slaets Joris P JP
Snieder Harold H
Stolk Ronald P RP
Wolffenbuttel Bruce H R BH
Wijmenga Cisca C
Forouhi Nita G N
Kerrison Nicola D ND
Langenberg Claudia C
Scott Robert A RA
Sharp Stephen J SJ
Sims Matt M
Barroso Inês I
Deloukas Panos P
McCarthy Mark I MI
Arriola Larraitz L
Balkau Beverley B
Barricarte Aurelio A
Boeing Heiner H
Franks Paul W PW
Gonzalez Carlos C
Grioni Sara S
Kaaks Rudolf R
Key Timothy J TJ
Navarro Carmen C
Nilsson Peter M PM
Overvad Kim K
Palli Domenico D
Panico Salvatore S
Quirós J Ramón J
Rolandsson Olov O
Sacerdote Carlotta C
Sánchez María-José MJ
Slimani Nadia N
Tjonneland Anne A
Tumino Rosario R
van der A Daphne L DL
van der Schouw Yvonne T YT
Riboli Elio E
Wareham Nicholas J NJ
Bowtell David D DD
Green Adele C A
Chenevix-Trench Georgia G
deFazio Anna A
Gertig Dorota D
Webb Penelope M PM
Brauch Hiltrud H
Justenhoven Christina C
Hamann Ute U
Ko Yon-Dschun YD
Baisch Christian C
Fischer Hans-Peter HP
Pesch Beate B
Rabstein Sylvia S
Spickenheuer Anne A
Harth Volker V
Aghmesheh Morteza M
Amor David D
Andrews Lesley L
Antill Yoland Y
Armitage Shane S
Arnold Leanne L
Balleine Rosemary R
Bankier Agnes A
Bastick Patti P
Beesley Jonathan J
Beilby John J
Bennett Ian I
Bennett Barbara B
Berry Geoffrey G
Blackburn Anneke A
Bogwitz Michael M
Brennan Meagan M
Brown Melissa M
Buckley Michael M
Burgess Matthew M
Burke Jo J
Butow Phyllis P
Byron Keith K
Callen David D
Campbell Ian I
Chauhan Deepa D
Chenevix-Trench Georgia G
Christian Alice A
Clarke Christine C
Colley Alison A
Cotton Dick D
Crook Ashley A
Cui James J
Culling Bronwyn B
Cummings Margaret M
Dawson Sarah-Jane SJ
deFazio Anna A
Delatycki Martin M
Dickson Rebecca R
Dixon Joanne J
Dobrovic Alexander A
Dudding Tracy T
Edkins Ted T
Edwards Stacey S
Eisenbruch Maurice M
Farshid Gelareh G
Fawcett Susan S
Fellows Andrew A
Fenton Georgina G
Field Michael M
Firgaira Frank F
Flanagan James J
Fleming Jean J
Fong Peter P
Forbes John J
Fox Stephen S
French Juliet J
Friedlander Michael M
Gaff Clara C
Gardner Mac M
Gattas Mike M
George Peter P
Giles Graham G
Gill Grantley G
Goldblatt Jack J
Greening Sian S
Grist Scott S
Eric Haan H
Hardie Kate K
Harris Marion M
Hart Stewart S
Hayward Nick N
Healey Sue S
Heiniger Louise L
Hopper John J
Humphrey Evelyn E
Hunt Clare C
James Paul P
Jenkins Mark M
Jones Alison A
Kefford Rick R
Kidd Alexa A
Kiely Belinda B
Kirk Judy J
Koehler Jessica J
Kollias James J
Kovalenko Serguei S
Lakhani Sunil S
Leaming Amanda A
Leary Jennifer J
Lim Jacqueline J
Lindeman Geoff G
Lipton Lara L
Lobb Liz L
Mann Graham G
Marsh Deborah D
McLachlan Sue Anne SA
Meiser Bettina B
Meldrum Cliff C
Milne Roger R
Mitchell Gillian G
Newman Beth B
O'Connell Shona S
O'Loughlin Imelda I
Osborne Richard R
Pachter Nick N
Patterson Briony B
Peters Lester L
Phillips Kelly K
Price Melanie M
Purser Lynne L
Reeve Jeanne J
Reeve Tony T
Richards Robert R
Rickard Edwina E
Robinson Bridget B
Rudzki Barney B
Saleh Mona M
Salisbury Elizabeth E
Sambrook Joe J
Saunders Christobel C
Saunus Jodi J
Sayer Robyn R
Scott Elizabeth E
Scott Rodney R
Scott Clare C
Seshadri Ram R
Sexton Adrienne A
Sharma Raghwa R
Shelling Andrew A
Simpson Peter P
Southey Melissa M
Spurdle Amanda A
Suthers Graeme G
Sykes Pamela P
Taylor Donna D
Taylor Jessica J
Thierry Benjamin B
Thompson Ella E
Thorne Heather H
Townshend Sharron S
Trainer Alison A
Tran Lan L
Tucker Kathy K
Tyler Janet J
Visvader Jane J
Walker Logan L
Walpole Ian I
Waring Paul P
Warner Bev B
Warren Graham G
Williams Rachael R
Wilson Judy J
Winship Ingrid I
Wu Kathy K
Young Mary Ann MA
JOURNAL
VOLUME: 514
ISSUE: 7520
TITLE: Nature
ISOABBREVIATION: Nature
YEAR: 2014
MONTH: Oct
DAY: 02
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-4687
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nature
COUNTRY: England
ISSNLINKING: 0028-0836
NLMUNIQUEID: 0410462
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
R01 NS017950 NINDS NIH HHS United States
MC_UU_12013/3 Medical Research Council United Kingdom
11022 Cancer Research UK United Kingdom
MC_UU_12015/1 Medical Research Council United Kingdom
MC_U106179471 Medical Research Council United Kingdom
MC_U106179472 Medical Research Council United Kingdom
098381 Wellcome Trust United Kingdom
10118 Cancer Research UK United Kingdom
G1000143 Medical Research Council United Kingdom
MR/J012165/1 Medical Research Council United Kingdom
R01 AG041517 NIA NIH HHS United States
UL1 TR001108 NCATS NIH HHS United States
102215 Wellcome Trust United Kingdom
MC_UU_12015/2 Medical Research Council United Kingdom
MC_PC_15018 Medical Research Council United Kingdom
P50 CA116201 NCI NIH HHS United States
G0401527 Medical Research Council United Kingdom
MC_UU_12013/1 Medical Research Council United Kingdom
G0701863 Medical Research Council United Kingdom
G9815508 Medical Research Council United Kingdom
10124 Cancer Research UK United Kingdom
U01 AG049505 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Age Factors
Alleles
Body Mass Index
Breast Neoplasms genetics
Calcium-Binding Proteins genetics
Cardiovascular Diseases genetics
Child genetics
Diabetes Mellitus, Type 2 genetics
Europe ethnology
Female ethnology
Genetic Loci genetics
Genome-Wide Association Study genetics
Genomic Imprinting genetics
Humans genetics
Hypothalamo-Hypophyseal System physiology
Intercellular Signaling Peptides and Proteins genetics
Male genetics
Membrane Proteins genetics
Menarche genetics
Obesity genetics
Ovary physiology
Parents physiology
Polymorphism, Single Nucleotide genetics
Potassium Channels, Tandem Pore Domain genetics
Proteins genetics
Quantitative Trait Loci genetics
Receptors, GABA-B metabolism
Receptors, Retinoic Acid metabolism
Ribonucleoproteins genetics
Ubiquitin-Protein Ligases genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Calcium-Binding Proteins
0 DLK1 protein, human
0 Intercellular Signaling Peptides and Proteins
0 KCNK9 protein, human
0 MAGEL2 protein, human
0 Membrane Proteins
0 Potassium Channels, Tandem Pore Domain
0 Proteins
0 Receptors, GABA-B
0 Receptors, Retinoic Acid
0 Ribonucleoproteins
0 WDR25 protein, human
EC 2.3.2.27 MKRN3 protein, human
EC 2.3.2.27 Ubiquitin-Protein Ligases
OTHER ID's
OTHERID SOURCE
EMS58897 NLM
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