Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
23738518
TITLE
A genome-wide association study for reading and language abilities in two population cohorts.
ABSTRACT
Candidate genes have been identified for both reading and language, but most of the heritable variance in these traits remains unexplained. Here, we report a genome-wide association meta-analysis of two large cohorts: population samples of Australian twins and siblings aged 12-25 years (n = 1177 from 538 families), and a younger cohort of children of the UK Avon Longitudinal Study of Parents and their Children (aged 8 and 9 years; maximum n = 5472). Suggestive association was indicated for reading measures and non-word repetition (NWR), with the greatest support found for single nucleotide polymorphisms (SNPs) in the pseudogene, ABCC13 (P = 7.34 × 10(-8)), and the gene, DAZAP1 (P = 1.32 × 10(-6)). Gene-based analyses showed significant association (P < 2.8 × 10(-6)) for reading and spelling with genes CD2L1, CDC2L2 and RCAN3 in two loci on chromosome 1. Some support was found for the same SNPs having effects on both reading skill and NWR, which is compatible with behavior genetic evidence for influences of reading acquisition on phonological-task performance. The results implicate novel candidates for study in additional cohorts for reading and language abilities.
© 2013 The Authors. Genes, Brain and Behavior published by John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
DATE PUBLISHED
2013 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2012/08/27
revised 2013/03/04
revised 2013/05/13
accepted 2013/05/24
aheadofprint 2013/06/20
entrez 2013/06/07 06:00
pubmed 2013/06/07 06:00
medline 2014/02/26 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Luciano M Luciano M M Centre for Cognitive Aging and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK. michelle.luciano@ed.ac.uk
Evans DM Evans D M DM
Hansell NK Hansell N K NK
Medland SE Medland S E SE
Montgomery GW Montgomery G W GW
Martin NG Martin N G NG
Wright MJ Wright M J MJ
Bates TC Bates T C TC
INVESTIGATORS
JOURNAL
VOLUME: 12
ISSUE: 6
TITLE: Genes, brain, and behavior
ISOABBREVIATION: Genes Brain Behav.
YEAR: 2013
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1601-183X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Genes Brain Behav
COUNTRY: England
ISSNLINKING: 1601-183X
NLMUNIQUEID: 101129617
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
092731 Wellcome Trust United Kingdom
G9815508 Medical Research Council United Kingdom
MC_PC_15018 Medical Research Council United Kingdom
Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
KEYWORD
Association
GWAS
dyslexia
genes
language
reading
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
ATP-Binding Cassette Transporters genetics
Adaptor Proteins, Signal Transducing genetics
Adolescent genetics
Adult genetics
Case-Control Studies genetics
Child genetics
Chromosomes, Human, Pair 1 genetics
Cyclin-Dependent Kinases genetics
Dyslexia genetics
Female genetics
Genetic Loci genetics
Genome-Wide Association Study genetics
Humans genetics
Language Development genetics
Language Tests genetics
Male genetics
Polymorphism, Single Nucleotide genetics
Population genetics
Pseudogenes genetics
RNA-Binding Proteins genetics
Reading genetics
Siblings genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 ABCC13 pseudogene, human
0 Adaptor Proteins, Signal Transducing
0 DAZAP1 protein, human
0 RCAN3 protein, human
0 RNA-Binding Proteins
EC 2.7.11.22 CDK11a protein, human
EC 2.7.11.22 Cyclin-Dependent Kinases
OTHER ID's
OTHERID SOURCE
PMC3908370 NLM
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