|
PMID |
|
|
TITLE |
|
FTO genotype is associated with phenotypic variability of body mass index. |
|
ABSTRACT |
|
|
|
There is evidence across several species for genetic control of phenotypic variation of complex traits, such that the variance among phenotypes is genotype dependent. Understanding genetic control of variability is important in evolutionary biology, agricultural selection programmes and human medicine, yet for complex traits, no individual genetic variants associated with variance, as opposed to the mean, have been identified. Here we perform a meta-analysis of genome-wide association studies of phenotypic variation using ∼170,000 samples on height and body mass index (BMI) in human populations. We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype), is also associated with phenotypic variability. We show that the results are not due to scale effects or other artefacts, and find no other experiment-wise significant evidence for effects on variability, either at loci other than FTO for BMI or at any locus for height. The difference in variance for BMI among individuals with opposite homozygous genotypes at the FTO locus is approximately 7%, corresponding to a difference of ∼0.5 kilograms in the standard deviation of weight. Our results indicate that genetic variants can be discovered that are associated with variability, and that between-person variability in obesity can partly be explained by the genotype at the FTO locus. The results are consistent with reported FTO by environment interactions for BMI, possibly mediated by DNA methylation. Our BMI results for other SNPs and our height results for all SNPs suggest that most genetic variants, including those that influence mean height or mean BMI, are not associated with phenotypic variance, or that their effects on variability are too small to detect even with samples sizes greater than 100,000. |
|
DATE PUBLISHED |
|
|
HISTORY |
|
PUBSTATUS |
PUBSTATUSDATE |
received |
2012/01/15 |
accepted |
2012/07/06 |
entrez |
2012/09/18 06:00 |
pubmed |
2012/09/18 06:00 |
medline |
2012/11/07 06:00 |
|
AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Yang J |
|
Yang |
Jian |
J |
|
University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia. |
Loos RJ |
|
Loos |
Ruth J F |
RJ |
|
|
Powell JE |
|
Powell |
Joseph E |
JE |
|
|
Medland SE |
|
Medland |
Sarah E |
SE |
|
|
Speliotes EK |
|
Speliotes |
Elizabeth K |
EK |
|
|
Chasman DI |
|
Chasman |
Daniel I |
DI |
|
|
Rose LM |
|
Rose |
Lynda M |
LM |
|
|
Thorleifsson G |
|
Thorleifsson |
Gudmar |
G |
|
|
Steinthorsdottir V |
|
Steinthorsdottir |
Valgerdur |
V |
|
|
Mägi R |
|
Mägi |
Reedik |
R |
|
|
Waite L |
|
Waite |
Lindsay |
L |
|
|
Smith AV |
|
Smith |
Albert Vernon |
AV |
|
|
Yerges-Armstrong LM |
|
Yerges-Armstrong |
Laura M |
LM |
|
|
Monda KL |
|
Monda |
Keri L |
KL |
|
|
Hadley D |
|
Hadley |
David |
D |
|
|
Mahajan A |
|
Mahajan |
Anubha |
A |
|
|
Li G |
|
Li |
Guo |
G |
|
|
Kapur K |
|
Kapur |
Karen |
K |
|
|
Vitart V |
|
Vitart |
Veronique |
V |
|
|
Huffman JE |
|
Huffman |
Jennifer E |
JE |
|
|
Wang SR |
|
Wang |
Sophie R |
SR |
|
|
Palmer C |
|
Palmer |
Cameron |
C |
|
|
Esko T |
|
Esko |
Tõnu |
T |
|
|
Fischer K |
|
Fischer |
Krista |
K |
|
|
Zhao JH |
|
Zhao |
Jing Hua |
JH |
|
|
Demirkan A |
|
Demirkan |
Ayşe |
A |
|
|
Isaacs A |
|
Isaacs |
Aaron |
A |
|
|
Feitosa MF |
|
Feitosa |
Mary F |
MF |
|
|
Luan J |
|
Luan |
Jian'an |
J |
|
|
Heard-Costa NL |
|
Heard-Costa |
Nancy L |
NL |
|
|
White C |
|
White |
Charles |
C |
|
|
Jackson AU |
|
Jackson |
Anne U |
AU |
|
|
Preuss M |
|
Preuss |
Michael |
M |
|
|
Ziegler A |
|
Ziegler |
Andreas |
A |
|
|
Eriksson J |
|
Eriksson |
Joel |
J |
|
|
Kutalik Z |
|
Kutalik |
Zoltán |
Z |
|
|
Frau F |
|
Frau |
Francesca |
F |
|
|
Nolte IM |
|
Nolte |
Ilja M |
IM |
|
|
Van Vliet-Ostaptchouk JV |
|
Van Vliet-Ostaptchouk |
Jana V |
JV |
|
|
Hottenga JJ |
|
Hottenga |
Jouke-Jan |
JJ |
|
|
Jacobs KB |
|
Jacobs |
Kevin B |
KB |
|
|
Verweij N |
|
Verweij |
Niek |
N |
|
|
Goel A |
|
Goel |
Anuj |
A |
|
|
Medina-Gomez C |
|
Medina-Gomez |
Carolina |
C |
|
|
Estrada K |
|
Estrada |
Karol |
K |
|
|
Bragg-Gresham JL |
|
Bragg-Gresham |
Jennifer Lynn |
JL |
|
|
Sanna S |
|
Sanna |
Serena |
S |
|
|
Sidore C |
|
Sidore |
Carlo |
C |
|
|
Tyrer J |
|
Tyrer |
Jonathan |
J |
|
|
Teumer A |
|
Teumer |
Alexander |
A |
|
|
Prokopenko I |
|
Prokopenko |
Inga |
I |
|
|
Mangino M |
|
Mangino |
Massimo |
M |
|
|
Lindgren CM |
|
Lindgren |
Cecilia M |
CM |
|
|
Assimes TL |
|
Assimes |
Themistocles L |
TL |
|
|
Shuldiner AR |
|
Shuldiner |
Alan R |
AR |
|
|
Hui J |
|
Hui |
Jennie |
J |
|
|
Beilby JP |
|
Beilby |
John P |
JP |
|
|
McArdle WL |
|
McArdle |
Wendy L |
WL |
|
|
Hall P |
|
Hall |
Per |
P |
|
|
Haritunians T |
|
Haritunians |
Talin |
T |
|
|
Zgaga L |
|
Zgaga |
Lina |
L |
|
|
Kolcic I |
|
Kolcic |
Ivana |
I |
|
|
Polasek O |
|
Polasek |
Ozren |
O |
|
|
Zemunik T |
|
Zemunik |
Tatijana |
T |
|
|
Oostra BA |
|
Oostra |
Ben A |
BA |
|
|
Junttila MJ |
|
Junttila |
M Juhani |
MJ |
|
|
Grönberg H |
|
Grönberg |
Henrik |
H |
|
|
Schreiber S |
|
Schreiber |
Stefan |
S |
|
|
Peters A |
|
Peters |
Annette |
A |
|
|
Hicks AA |
|
Hicks |
Andrew A |
AA |
|
|
Stephens J |
|
Stephens |
Jonathan |
J |
|
|
Foad NS |
|
Foad |
Nicola S |
NS |
|
|
Laitinen J |
|
Laitinen |
Jaana |
J |
|
|
Pouta A |
|
Pouta |
Anneli |
A |
|
|
Kaakinen M |
|
Kaakinen |
Marika |
M |
|
|
Willemsen G |
|
Willemsen |
Gonneke |
G |
|
|
Vink JM |
|
Vink |
Jacqueline M |
JM |
|
|
Wild SH |
|
Wild |
Sarah H |
SH |
|
|
Navis G |
|
Navis |
Gerjan |
G |
|
|
Asselbergs FW |
|
Asselbergs |
Folkert W |
FW |
|
|
Homuth G |
|
Homuth |
Georg |
G |
|
|
John U |
|
John |
Ulrich |
U |
|
|
Iribarren C |
|
Iribarren |
Carlos |
C |
|
|
Harris T |
|
Harris |
Tamara |
T |
|
|
Launer L |
|
Launer |
Lenore |
L |
|
|
Gudnason V |
|
Gudnason |
Vilmundur |
V |
|
|
O'Connell JR |
|
O'Connell |
Jeffrey R |
JR |
|
|
Boerwinkle E |
|
Boerwinkle |
Eric |
E |
|
|
Cadby G |
|
Cadby |
Gemma |
G |
|
|
Palmer LJ |
|
Palmer |
Lyle J |
LJ |
|
|
James AL |
|
James |
Alan L |
AL |
|
|
Musk AW |
|
Musk |
Arthur W |
AW |
|
|
Ingelsson E |
|
Ingelsson |
Erik |
E |
|
|
Psaty BM |
|
Psaty |
Bruce M |
BM |
|
|
Beckmann JS |
|
Beckmann |
Jacques S |
JS |
|
|
Waeber G |
|
Waeber |
Gerard |
G |
|
|
Vollenweider P |
|
Vollenweider |
Peter |
P |
|
|
Hayward C |
|
Hayward |
Caroline |
C |
|
|
Wright AF |
|
Wright |
Alan F |
AF |
|
|
Rudan I |
|
Rudan |
Igor |
I |
|
|
Groop LC |
|
Groop |
Leif C |
LC |
|
|
Metspalu A |
|
Metspalu |
Andres |
A |
|
|
Khaw KT |
|
Khaw |
Kay Tee |
KT |
|
|
van Duijn CM |
|
van Duijn |
Cornelia M |
CM |
|
|
Borecki IB |
|
Borecki |
Ingrid B |
IB |
|
|
Province MA |
|
Province |
Michael A |
MA |
|
|
Wareham NJ |
|
Wareham |
Nicholas J |
NJ |
|
|
Tardif JC |
|
Tardif |
Jean-Claude |
JC |
|
|
Huikuri HV |
|
Huikuri |
Heikki V |
HV |
|
|
Cupples LA |
|
Cupples |
L Adrienne |
LA |
|
|
Atwood LD |
|
Atwood |
Larry D |
LD |
|
|
Fox CS |
|
Fox |
Caroline S |
CS |
|
|
Boehnke M |
|
Boehnke |
Michael |
M |
|
|
Collins FS |
|
Collins |
Francis S |
FS |
|
|
Mohlke KL |
|
Mohlke |
Karen L |
KL |
|
|
Erdmann J |
|
Erdmann |
Jeanette |
J |
|
|
Schunkert H |
|
Schunkert |
Heribert |
H |
|
|
Hengstenberg C |
|
Hengstenberg |
Christian |
C |
|
|
Stark K |
|
Stark |
Klaus |
K |
|
|
Lorentzon M |
|
Lorentzon |
Mattias |
M |
|
|
Ohlsson C |
|
Ohlsson |
Claes |
C |
|
|
Cusi D |
|
Cusi |
Daniele |
D |
|
|
Staessen JA |
|
Staessen |
Jan A |
JA |
|
|
Van der Klauw MM |
|
Van der Klauw |
Melanie M |
MM |
|
|
Pramstaller PP |
|
Pramstaller |
Peter P |
PP |
|
|
Kathiresan S |
|
Kathiresan |
Sekar |
S |
|
|
Jolley JD |
|
Jolley |
Jennifer D |
JD |
|
|
Ripatti S |
|
Ripatti |
Samuli |
S |
|
|
Jarvelin MR |
|
Jarvelin |
Marjo-Riitta |
MR |
|
|
de Geus EJ |
|
de Geus |
Eco J C |
EJ |
|
|
Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
|
Penninx B |
|
Penninx |
Brenda |
B |
|
|
Wilson JF |
|
Wilson |
James F |
JF |
|
|
Campbell H |
|
Campbell |
Harry |
H |
|
|
Chanock SJ |
|
Chanock |
Stephen J |
SJ |
|
|
van der Harst P |
|
van der Harst |
Pim |
P |
|
|
Hamsten A |
|
Hamsten |
Anders |
A |
|
|
Watkins H |
|
Watkins |
Hugh |
H |
|
|
Hofman A |
|
Hofman |
Albert |
A |
|
|
Witteman JC |
|
Witteman |
Jacqueline C |
JC |
|
|
Zillikens MC |
|
Zillikens |
M Carola |
MC |
|
|
Uitterlinden AG |
|
Uitterlinden |
André G |
AG |
|
|
Rivadeneira F |
|
Rivadeneira |
Fernando |
F |
|
|
Zillikens MC |
|
Zillikens |
M Carola |
MC |
|
|
Kiemeney LA |
|
Kiemeney |
Lambertus A |
LA |
|
|
Vermeulen SH |
|
Vermeulen |
Sita H |
SH |
|
|
Abecasis GR |
|
Abecasis |
Goncalo R |
GR |
|
|
Schlessinger D |
|
Schlessinger |
David |
D |
|
|
Schipf S |
|
Schipf |
Sabine |
S |
|
|
Stumvoll M |
|
Stumvoll |
Michael |
M |
|
|
Tönjes A |
|
Tönjes |
Anke |
A |
|
|
Spector TD |
|
Spector |
Tim D |
TD |
|
|
North KE |
|
North |
Kari E |
KE |
|
|
Lettre G |
|
Lettre |
Guillaume |
G |
|
|
McCarthy MI |
|
McCarthy |
Mark I |
MI |
|
|
Berndt SI |
|
Berndt |
Sonja I |
SI |
|
|
Heath AC |
|
Heath |
Andrew C |
AC |
|
|
Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
Nyholt DR |
|
Nyholt |
Dale R |
DR |
|
|
Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
McKnight B |
|
McKnight |
Barbara |
B |
|
|
Strachan DP |
|
Strachan |
David P |
DP |
|
|
Hill WG |
|
Hill |
William G |
WG |
|
|
Snieder H |
|
Snieder |
Harold |
H |
|
|
Ridker PM |
|
Ridker |
Paul M |
PM |
|
|
Thorsteinsdottir U |
|
Thorsteinsdottir |
Unnur |
U |
|
|
Stefansson K |
|
Stefansson |
Kari |
K |
|
|
Frayling TM |
|
Frayling |
Timothy M |
TM |
|
|
Hirschhorn JN |
|
Hirschhorn |
Joel N |
JN |
|
|
Goddard ME |
|
Goddard |
Michael E |
ME |
|
|
Visscher PM |
|
Visscher |
Peter M |
PM |
|
|
|
INVESTIGATORS |
|
|
JOURNAL |
|
VOLUME: 490 |
ISSUE: 7419 |
TITLE: Nature |
ISOABBREVIATION: Nature |
YEAR: 2012 |
MONTH: Oct |
DAY: 11 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1476-4687 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Nature |
COUNTRY: England |
ISSNLINKING: 0028-0836 |
NLMUNIQUEID: 0410462 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Meta-Analysis |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
|
COMMENTS AND CORRECTIONS |
|
REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
Cites |
Clin Genet. 1983 Jul;24(1):1-14 |
6684513 |
|
Cites |
Genetics. 2004 Dec;168(4):2089-97 |
15611178 |
|
Cites |
Philos Trans R Soc Lond B Biol Sci. 2005 Jul 29;360(1459):1513-27 |
16108138 |
|
Cites |
Science. 2007 May 11;316(5826):889-94 |
17434869 |
|
Cites |
Bioinformatics. 2007 May 15;23(10):1294-6 |
17384015 |
|
Cites |
Nat Genet. 2007 Jun;39(6):724-6 |
17496892 |
|
Cites |
Nat Genet. 2007 Jul;39(7):906-13 |
17572673 |
|
Cites |
Nature. 2007 Oct 18;449(7164):851-61 |
17943122 |
|
Cites |
Diabetes. 2008 Jan;57(1):95-101 |
17942823 |
|
Cites |
PLoS Genet. 2008 Apr;4(4):e1000049 |
18404214 |
|
Cites |
PLoS Genet. 2007 Jul;3(7):e115 |
17658951 |
|
Cites |
Arch Intern Med. 2008 Sep 8;168(16):1791-7 |
18779467 |
|
Cites |
Genet Res (Camb). 2008 Oct;90(5):385-95 |
19061529 |
|
Cites |
Poult Sci. 2009 Jun;88(6):1156-61 |
19439624 |
|
Cites |
Am J Clin Nutr. 2009 Oct;90(4):1096-103 |
19710197 |
|
Cites |
PLoS Genet. 2010 Jun;6(6):e1000981 |
20585554 |
|
Cites |
Behav Genet. 2010 Sep;40(5):728-33 |
20428936 |
|
Cites |
Bioinformatics. 2010 Sep 1;26(17):2190-1 |
20616382 |
|
Cites |
Bioinformatics. 2010 Sep 15;26(18):2336-7 |
20634204 |
|
Cites |
Nature. 2010 Oct 14;467(7317):832-8 |
20881960 |
|
Cites |
Nat Genet. 2010 Nov;42(11):937-48 |
20935630 |
|
Cites |
BMC Genet. 2010;11:92 |
20942902 |
|
Cites |
Genet Epidemiol. 2010 Dec;34(8):816-34 |
21058334 |
|
Cites |
PLoS One. 2010;5(11):e14040 |
21124985 |
|
Cites |
Genet Res (Camb). 2010 Dec;92(5-6):381-95 |
21429270 |
|
Cites |
Genetics. 2011 Jun;188(2):435-47 |
21467569 |
|
Cites |
PLoS Genet. 2011 Sep;7(9):e1002295 |
21980300 |
|
Cites |
PLoS Med. 2011 Nov;8(11):e1001116 |
22069379 |
|
Cites |
Nat Chem Biol. 2011 Dec;7(12):885-7 |
22002720 |
|
Cites |
Hum Mol Genet. 2012 Jan 15;21(2):371-83 |
21994764 |
|
Cites |
PLoS One. 2012;7(1):e28764 |
22235250 |
|
Cites |
Genomics. 2012 Mar;99(3):132-7 |
22234326 |
|
Cites |
Genet Res (Camb). 2011 Apr;93(2):125-38 |
21392419 |
|
Cites |
Biometrics. 1999 Dec;55(4):997-1004 |
11315092 |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
R01 LM010098 |
NLM NIH HHS |
United States |
AA014041 |
NIAAA NIH HHS |
United States |
R01 AG020098 |
NIA NIH HHS |
United States |
P30 DK020572 |
NIDDK NIH HHS |
United States |
RL1 MH083268 |
NIMH NIH HHS |
United States |
R01 AA013320 |
NIAAA NIH HHS |
United States |
HHSN268201100012C |
NHLBI NIH HHS |
United States |
UL1 RR033176 |
NCRR NIH HHS |
United States |
CZB/4/710 |
Chief Scientist Office |
United Kingdom |
R01 DK073490 |
NIDDK NIH HHS |
United States |
K23 DK080145 |
NIDDK NIH HHS |
United States |
R01 MH063706 |
NIMH NIH HHS |
United States |
R01 AA007535 |
NIAAA NIH HHS |
United States |
R01 HL075366 |
NHLBI NIH HHS |
United States |
R01 AA014041 |
NIAAA NIH HHS |
United States |
K05 AA017688 |
NIAAA NIH HHS |
United States |
N01 AG012100 |
NIA NIH HHS |
United States |
R01 HL087647 |
NHLBI NIH HHS |
United States |
U01 HL084729 |
NHLBI NIH HHS |
United States |
HHSN268201100010C |
NHLBI NIH HHS |
United States |
N01 HG065403 |
NHGRI NIH HHS |
United States |
AA13320 |
NIAAA NIH HHS |
United States |
R01 AG015928 |
NIA NIH HHS |
United States |
U01 HL054527 |
NHLBI NIH HHS |
United States |
HHSN268201100008C |
NHLBI NIH HHS |
United States |
R01 HL087679 |
NHLBI NIH HHS |
United States |
R01 HL087676 |
NHLBI NIH HHS |
United States |
R01 HG002651 |
NHGRI NIH HHS |
United States |
N01 HC075150 |
NHLBI NIH HHS |
United States |
R01 HL043851 |
NHLBI NIH HHS |
United States |
R01 HL059367 |
NHLBI NIH HHS |
United States |
U01 HG006513 |
NHGRI NIH HHS |
United States |
HHSN268201100007C |
NHLBI NIH HHS |
United States |
MC_U127561128 |
Medical Research Council |
United Kingdom |
DA12854 |
NIDA NIH HHS |
United States |
N01 HC015103 |
NHLBI NIH HHS |
United States |
AA13321 |
NIAAA NIH HHS |
United States |
AA10248 |
NIAAA NIH HHS |
United States |
R01 DK072193 |
NIDDK NIH HHS |
United States |
N01 HC025195 |
NHLBI NIH HHS |
United States |
HHSN268201100011C |
NHLBI NIH HHS |
United States |
R01 HL086694 |
NHLBI NIH HHS |
United States |
N02 HL64278 |
NHLBI NIH HHS |
United States |
R01 AA013326 |
NIAAA NIH HHS |
United States |
G1000143 |
Medical Research Council |
United Kingdom |
Z01 HG000024-14 |
Intramural NIH HHS |
United States |
R56 DA012854 |
NIDA NIH HHS |
United States |
R01 HL087652 |
NHLBI NIH HHS |
United States |
F32 DK079466 |
NIDDK NIH HHS |
United States |
U01 HG004402 |
NHGRI NIH HHS |
United States |
R01 DK075787 |
NIDDK NIH HHS |
United States |
R01 DK075681 |
NIDDK NIH HHS |
United States |
N01HC85086 |
NHLBI NIH HHS |
United States |
R01 AA013321 |
NIAAA NIH HHS |
United States |
R01 DK062370 |
NIDDK NIH HHS |
United States |
R01 HL105756 |
NHLBI NIH HHS |
United States |
MC_U106179471 |
Medical Research Council |
United Kingdom |
U01 HL084756 |
NHLBI NIH HHS |
United States |
U01 DK062418 |
NIDDK NIH HHS |
United States |
P30 DK063491 |
NIDDK NIH HHS |
United States |
HHSN268201100006C |
NHLBI NIH HHS |
United States |
P30 DK072488 |
NIDDK NIH HHS |
United States |
14136 |
Cancer Research UK |
United Kingdom |
GM057091 |
NIGMS NIH HHS |
United States |
N01 HC055222 |
NHLBI NIH HHS |
United States |
G0401527 |
Medical Research Council |
United Kingdom |
090532 |
Wellcome Trust |
United Kingdom |
MC_PC_U127561128 |
Medical Research Council |
United Kingdom |
U01 HL072515 |
NHLBI NIH HHS |
United States |
R01 HL080295 |
NHLBI NIH HHS |
United States |
R01 DA012854 |
NIDA NIH HHS |
United States |
HHSN268201100009C |
NHLBI NIH HHS |
United States |
HHSN268201100005C |
NHLBI NIH HHS |
United States |
N01 HC085079 |
NHLBI NIH HHS |
United States |
F32 AR059469 |
NIAMS NIH HHS |
United States |
R01 AG023629 |
NIA NIH HHS |
United States |
R01 HL087641 |
NHLBI NIH HHS |
United States |
R01 AG027058 |
NIA NIH HHS |
United States |
N01 HC045133 |
NHLBI NIH HHS |
United States |
G0601261 |
Medical Research Council |
United Kingdom |
U01 HL069757 |
NHLBI NIH HHS |
United States |
N01 HC035129 |
NHLBI NIH HHS |
United States |
U54 RR020278 |
NCRR NIH HHS |
United States |
AA13326 |
NIAAA NIH HHS |
United States |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Alpha-Ketoglutarate-Dependent Dioxygenase FTO |
|
Body Height |
genetics |
Body Mass Index |
genetics |
Co-Repressor Proteins |
genetics |
Female |
genetics |
Genetic Variation |
genetics |
Genome-Wide Association Study |
genetics |
Humans |
genetics |
Male |
genetics |
Nerve Tissue Proteins |
genetics |
Phenotype |
genetics |
Polymorphism, Single Nucleotide |
genetics |
Proteins |
genetics |
Repressor Proteins |
genetics |
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
REGISTRYNUMBER |
NAMEOFSUBSTANCE |
0 |
Co-Repressor Proteins |
0 |
Nerve Tissue Proteins |
0 |
Proteins |
0 |
RCOR1 protein, human |
0 |
Repressor Proteins |
EC 1.14.11.33 |
Alpha-Ketoglutarate-Dependent Dioxygenase FTO |
EC 1.14.11.33 |
FTO protein, human |
|
OTHER ID's |
|
|
|