Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
22856364
TITLE
Alzheimer's disease risk gene, GAB2, is associated with regional brain volume differences in 755 young healthy twins.
ABSTRACT
The development of late-onset Alzheimer's disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27-1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer's disease.
DATE PUBLISHED
2012 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2012/08/04 06:00
pubmed 2012/08/04 06:00
medline 2012/09/26 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hibar DP Hibar Derrek P DP Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA.
Jahanshad N Jahanshad Neda N
Stein JL Stein Jason L JL
Kohannim O Kohannim Omid O
Toga AW Toga Arthur W AW
Medland SE Medland Sarah E SE
Hansell NK Hansell Narelle K NK
McMahon KL McMahon Katie L KL
de Zubicaray GI de Zubicaray Greig I GI
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME: 15
ISSUE: 3
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2012
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Am J Hum Genet. 2011 Mar 11;88(3):283-93 21397060
Cites J Nutr Health Aging. 2009 Mar;13(3):214-9 19262956
Cites Neuroimage. 2011 Jun 15;56(4):1875-91 21497199
Cites Neurobiol Aging. 2011 Aug;32(8):1341-71 19775776
Cites J Psychiatr Res. 2011 Aug;45(8):995-1004 21550050
Cites Mol Psychiatry. 2011 Sep;16(9):960-72 20733577
Cites IEEE Trans Med Imaging. 2011 Sep;30(9):1617-34 21880566
Cites World J Biol Psychiatry. 2012 Mar;13(3):178-87 21722019
Cites Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):E851-9 22232660
Cites Nat Genet. 2012 May;44(5):552-61 22504417
Cites Nat Genet. 2012 May;44(5):545-51 22504421
Cites Arch Gen Psychiatry. 2012 Sep;69(9):875-84 22945617
Cites Biochem Biophys Res Commun. 2000 Oct 14;277(1):195-9 11027663
Cites Nat Neurosci. 2001 Dec;4(12):1253-8 11694885
Cites Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4703-7 11930016
Cites J Neurol Neurosurg Psychiatry. 2002 Jun;72(6):742-6 12023417
Cites Am J Psychiatry. 2003 Apr;160(4):636-45 12668349
Cites Neuroimage. 2009 Apr 15;45(3):645-55 19280686
Cites Neuroimage. 2009 May 1;45(4):1107-16 19349228
Cites Biol Psychiatry. 2009 Jun 1;65(11):995-9 19118819
Cites Neuroimage. 2010 Jan 15;49(2):1213-23 19786105
Cites Science. 2010 Mar 26;327(5973):1580-1 20339051
Cites Neurol Sci. 2010 Jun;31(3):277-81 19924507
Cites Curr Opin Neurol. 2010 Aug;23(4):368-73 20581684
Cites Nature. 2010 Sep 2;467(7311):52-8 20811451
Cites Genet Epidemiol. 2010 Dec;34(8):816-34 21058334
Cites Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1489-99 20926767
Cites Neuroimage. 2011 Feb 1;54(3):1896-902 20888920
Cites PLoS One. 2010;5(12):e14480 21217833
Cites Neuroimage. 2011 Mar 15;55(2):448-54 21195196
Cites Br J Psychol. 1970 Aug;61(3):303-21 5457503
Cites J Nucl Med. 1996 Feb;37(2):201-8 8667045
Cites Cereb Cortex. 1996 Jan-Feb;6(1):50-61 8670638
Cites J Neurosci. 1997 Feb 1;17(3):1046-54 8994059
Cites Neurology. 1997 Sep;49(3):786-94 9305341
Cites Neurobiol Aging. 1997 Jul-Aug;18(4):351-7 9330961
Cites J Comput Assist Tomogr. 1998 Mar-Apr;22(2):324-33 9530404
Cites Neurology. 1998 Oct;51(4):993-9 9781519
Cites J Biol Chem. 1999 Jul 9;274(28):19649-54 10391903
Cites J Neurosci. 2004 Nov 10;24(45):10099-102 15537879
Cites Neuroimage. 2005 Apr 15;25(3):653-60 15808966
Cites Nat Rev Neurosci. 2006 Oct;7(10):818-27 16988657
Cites Inf Process Med Imaging. 2005;19:493-503 17354720
Cites Hum Brain Mapp. 2007 Jun;28(6):464-73 17415783
Cites Lancet Neurol. 2007 Jun;6(6):494-500 17509484
Cites Nature. 2007 Jun 7;447(7145):661-78 17554300
Cites Neuron. 2007 Jun 7;54(5):713-20 17553421
Cites Neuroimage. 2007 Oct 15;38(1):43-56 17825583
Cites Genet Epidemiol. 2008 Feb;32(2):108-18 17849491
Cites Neurobiol Dis. 2008 Apr;30(1):103-6 18272374
Cites Genetics. 2008 Mar;178(3):1709-23 18385116
Cites Arch Neurol. 2009 Feb;66(2):250-4 19204163
Cites J Neurosci. 2011 May 4;31(18):6764-70 21543606
GRANTS
GRANTID AGENCY COUNTRY
R01 HD050735 NICHD NIH HHS United States
T15 LM007356 NLM NIH HHS United States
T32 GM008042 NIGMS NIH HHS United States
T15 LM07356 NLM NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adaptor Proteins, Signal Transducing genetics
Adult genetics
Age of Onset genetics
Alzheimer Disease pathology
Analysis of Variance pathology
Brain pathology
Diseases in Twins genetics
Female genetics
Genetic Predisposition to Disease genetics
Genotype genetics
Humans genetics
Magnetic Resonance Imaging genetics
Male genetics
Organ Size genetics
Polymorphism, Single Nucleotide genetics
Principal Component Analysis genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Adaptor Proteins, Signal Transducing
0 GAB2 protein, human
OTHER ID's
Designed by: GenEpi IT
Maintained by: GenEpi IT
Feedback: webmaster
Copyright © 2007 QIMR
For more information Contact Us
epiit@qimr.edu.au
Last Modified: Oct 15 2007