| PMID |
|
|
| TITLE |
|
| The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation. |
|
| ABSTRACT |
|
|
|
| While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use. |
| © 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2012/07/25 06:00 |
| pubmed |
2012/07/25 06:00 |
| medline |
2014/03/13 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Verweij KJ |
|
Verweij |
Karin J H |
KJ |
|
Queensland Institute of Medical Research, Australia. karin.verweij@qimr.edu.au |
| Vinkhuyzen AA |
|
Vinkhuyzen |
Anna A E |
AA |
|
|
| Benyamin B |
|
Benyamin |
Beben |
B |
|
|
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
|
| Quaye L |
|
Quaye |
Lydia |
L |
|
|
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
|
| Gordon SD |
|
Gordon |
Scott D |
SD |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Spector TD |
|
Spector |
Timothy D |
TD |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Medland SE |
|
Medland |
Sarah E |
SE |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 18 |
| ISSUE: 5 |
| TITLE: Addiction biology |
| ISOABBREVIATION: Addict Biol |
| YEAR: 2013 |
| MONTH: Sep |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1369-1600 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Addict Biol |
| COUNTRY: United States |
| ISSNLINKING: 1355-6215 |
| NLMUNIQUEID: 9604935 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Meta-Analysis |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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17254428 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 AA014041 |
NIAAA NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| AA13320 |
NIAAA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| R01 DA023668 |
NIDA NIH HHS |
United States |
| R01 AA013326 |
NIAAA NIH HHS |
United States |
| R56 DA012854 |
NIDA NIH HHS |
United States |
| AA013326 |
NIAAA NIH HHS |
United States |
| R01 AA013321 |
NIAAA NIH HHS |
United States |
| R01 DA012854 |
NIDA NIH HHS |
United States |
| AA014041 |
NIAAA NIH HHS |
United States |
| AA013321 |
NIAAA NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
| R01 AA013320 |
NIAAA NIH HHS |
United States |
| DA23668 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Association |
| cannabis |
| genetics |
| heritability |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Australia |
epidemiology |
| Female |
epidemiology |
| Genetic Predisposition to Disease |
genetics |
| Genome-Wide Association Study |
genetics |
| Genotype |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Marijuana Abuse |
genetics |
| Middle Aged |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
| Twin Studies as Topic |
genetics |
| United Kingdom |
epidemiology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
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|
