Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17955480
TITLE
A genome-wide linkage study in families with major depression and co-morbid unexplained swelling.
ABSTRACT
Major depressive disorder (MDD) is a common heritable condition. The diversity of the phenotype coupled with aetiological and genetic heterogeneity present formidable obstacles in the search for causative genetic loci. Studies of large families with many affected individuals, and the selection of well-defined clinical subgroups of depression, are two ways to reduce this complexity. Unexplained swelling symptoms (USS) are common in women and many patients give a strong personal and family history of depression. Co-morbid depression and swelling symptoms define a useful sub-phenotype for investigating genetic factors in depression. We have completed a genome-wide linkage analysis using 371 microsatellite markers in four families where MDD is co-morbid with USS. Of 47 affected individuals, 28 had both MDD and unexplained swelling, 11 had symptoms of swelling alone, and 8 had MDD alone. Parametric marker-specific analysis identified one suggestive locus, D8S260 (LOD = 2.02) and non-parametric multipoint variance component analysis identified a region on 7p (LOD = 2.10). A 47 cM suggestive linkage region on chromosome 14q (identified by both parametric and non-parametric methods) was identified and investigated further with fine-mapping markers but the evidence for linkage to this region decreased with increased marker information content.
Copyright 2007 Wiley-Liss, Inc.
DATE PUBLISHED
2008 Apr 5
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2007/10/24 09:00
medline 2008/08/09 09:00
entrez 2007/10/24 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Anderson CA Anderson Carl A CA Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
Maclean A Maclean Alan A
Dunnigan MG Dunnigan Matthew G MG
Pelosi AJ Pelosi Anthony J AJ
Murray V Murray Valerie V
McKee I McKee Irene I
McDonald G McDonald George G
Burt DW Burt David W DW
Morrice DR Morrice David R DR
Muir WJ Muir Walter J WJ
Visscher PM Visscher Peter M PM
Blackwood DH Blackwood Douglas H R DH
INVESTIGATORS
JOURNAL
VOLUME: 147
ISSUE: 3
TITLE: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISOABBREVIATION: Am. J. Med. Genet. B Neuropsychiatr. Genet.
YEAR: 2008
MONTH: Apr
DAY: 5
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1552-485X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet B Neuropsychiatr Genet
COUNTRY: United States
ISSNLINKING: 1552-4841
NLMUNIQUEID: 101235742
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
Biotechnology and Biological Sciences Research Council United Kingdom
Medical Research Council United Kingdom
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Depressive Disorder, Major genetics
Edema genetics
Female genetics
Genetic Linkage genetics
Genome, Human genetics
Genotype genetics
Humans genetics
Male genetics
Middle Aged genetics
Pedigree genetics
Phenotype genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's