Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17924350
TITLE
Genome partitioning of genetic variation for height from 11,214 sibling pairs.
ABSTRACT
Height has been used for more than a century as a model by which to understand quantitative genetic variation in humans. We report that the entire genome appears to contribute to its additive genetic variance. We used genotypes and phenotypes of 11,214 sibling pairs from three countries to partition additive genetic variance across the genome. Using genome scans to estimate the proportion of the genomes of each chromosome from siblings that were identical by descent, we estimated the heritability of height contributed by each of the 22 autosomes and the X chromosome. We show that additive genetic variance is spread across multiple chromosomes and that at least six chromosomes (i.e., 3, 4, 8, 15, 17, and 18) are responsible for the observed variation. Indeed, the data are not inconsistent with a uniform spread of trait loci throughout the genome. Our estimate of the variance explained by a chromosome is correlated with the number of times suggestive or significant linkage with height has been reported for that chromosome. Variance due to dominance was not significant but was difficult to assess because of the high sampling correlation between additive and dominance components. Results were consistent with the absence of any large between-chromosome epistatic effects. Notwithstanding the proposed architecture of complex traits that involves widespread gene-gene and gene-environment interactions, our results suggest that variation in height in humans can be explained by many loci distributed over all autosomes, with an additive mode of gene action.
DATE PUBLISHED
2007 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2007/05/24
accepted 2007/07/24
pubmed 2007/10/10 09:00
medline 2007/12/06 09:00
entrez 2007/10/10 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Visscher PM Visscher Peter M PM Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Australia. peter.visscher@qimr.edu.au
Macgregor S Macgregor Stuart S
Benyamin B Benyamin Beben B
Zhu G Zhu Gu G
Gordon S Gordon Scott S
Medland S Medland Sarah S
Hill WG Hill William G WG
Hottenga JJ Hottenga Jouke-Jan JJ
Willemsen G Willemsen Gonneke G
Boomsma DI Boomsma Dorret I DI
Liu YZ Liu Yao-Zhong YZ
Deng HW Deng Hong-Wen HW
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 81
ISSUE: 5
TITLE: American journal of human genetics
ISOABBREVIATION: Am J Hum Genet
YEAR: 2007
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0002-9297
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Hum Genet
COUNTRY: United States
ISSNLINKING: 0002-9297
NLMUNIQUEID: 0370475
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Adv Genet. 2001;42:299-322 11037329
Cites Am J Hum Genet. 2001 Jul;69(1):106-16 11410839
Cites Am J Hum Genet. 2001 Jul;69(1):117-23 11410840
Cites Nat Genet. 2002 Jan;30(1):97-101 11731797
Cites Am J Hum Genet. 2002 Feb;70(2):543-6 11753821
Cites Nat Rev Genet. 2002 Jan;3(1):11-21 11823787
Cites Nat Genet. 2002 Jul;31(3):235-6 12089518
Cites Am J Hum Genet. 2002 Sep;71(3):646-50 12119602
Cites Science. 2002 Dec 20;298(5602):2345-9 12493905
Cites Bioinformatics. 2003 Jan;19(1):149-50 12499305
Cites J Biosoc Sci. 2003 Apr;35(2):263-85 12664962
Cites Hum Hered. 2003;55(4):191-201 14566097
Cites Twin Res. 2003 Oct;6(5):399-408 14624724
Cites Behav Genet. 2004 Jul;34(4):477-82 15082944
Cites Twin Res. 2004 Apr;7(2):197-210 15169604
Cites Nat Rev Genet. 2004 Aug;5(8):618-25 15266344
Cites Science. 2004 Aug 6;305(5685):869-72 15297675
Cites Eur J Hum Genet. 2004 Oct;12(10):820-8 15305175
Cites Am J Hum Genet. 2004 Dec;75(6):1143-8 15486828
Cites Genetics. 1971 Nov;69(3):353-61 5002803
Cites Am J Hum Genet. 1990 Dec;47(6):957-67 2239972
Cites Nat Genet. 1995 Nov;11(3):241-7 7581446
Cites Heredity (Edinb). 1950 Dec;4(3):295-312 14802987
Cites Ann Hum Genet. 2005 Sep;69(Pt 5):517-27 16138910
Cites Genet Epidemiol. 2005 Nov;29(3):215-24 16121355
Cites Genet Epidemiol. 2005 Dec;29(4):377-88 16294301
Cites J Med Genet. 2005 Dec;42(12):932-9 15827092
Cites Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3502-9 16537441
Cites Hum Genet. 2006 Apr;119(3):295-304 16446976
Cites Nat Genet. 2006 Jun;38(6):617-9 16699517
Cites PLoS Genet. 2006 Mar;2(3):e41 16565746
Cites Hum Mol Genet. 2006 Sep 15;15(18):2772-83 16905557
Cites Science. 2006 Dec 1;314(5804):1461-3 17068223
Cites Nat Genet. 2007 Feb;39(2):207-11 17200669
Cites Nature. 2007 Jun 7;447(7145):661-78 17554300
GRANTS
GRANTID AGENCY COUNTRY
R01 AA007535 NIAAA NIH HHS United States
R01 AA014041 NIAAA NIH HHS United States
N01HG65403 NHGRI NIH HHS United States
AA013320 NIAAA NIH HHS United States
P50 AA011998 NIAAA NIH HHS United States
R01 AA007728 NIAAA NIH HHS United States
R01 AA013326 NIAAA NIH HHS United States
AA013326 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
R01 GM060402 NIGMS NIH HHS United States
AA014041 NIAAA NIH HHS United States
R01 AA010249 NIAAA NIH HHS United States
K01 AR002170 NIAMS NIH HHS United States
R37 AA007728 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
N01HV48141 NHLBI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Australia
Body Height genetics
Chromosomes, Human genetics
Databases, Genetic genetics
Female genetics
Genetic Variation genetics
Genome, Human genetics
Humans genetics
Male genetics
Quantitative Trait, Heritable genetics
Siblings genetics
United States genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's